Convenient Synthesis of Functionalized Cyclopropa[c]coumarin-1a-carboxylates

A simple method has been developed for the synthesis of cyclopropa[c]coumarins, which belong to the donor-acceptor cyclopropane family and, therefore, are promising substrates for the preparation of chromene-based fine chemicals. The method, based on the acetic acid-induced intramolecular transester...

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Detalles Bibliográficos
Autores principales: Ivanova, Olga A., Andronov, Vladimir A., Levina, Irina I., Chagarovskiy, Alexey O., Voskressensky, Leonid G., Trushkov, Igor V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337311/
https://www.ncbi.nlm.nih.gov/pubmed/30586901
http://dx.doi.org/10.3390/molecules24010057
Descripción
Sumario:A simple method has been developed for the synthesis of cyclopropa[c]coumarins, which belong to the donor-acceptor cyclopropane family and, therefore, are promising substrates for the preparation of chromene-based fine chemicals. The method, based on the acetic acid-induced intramolecular transesterification of 2-arylcyclopropane-1,1-dicarboxylates, was found to be efficient for substrates containing hydroxy group directly attached to the aromatic ring.

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