Convenient Synthesis of Functionalized Cyclopropa[c]coumarin-1a-carboxylates

A simple method has been developed for the synthesis of cyclopropa[c]coumarins, which belong to the donor-acceptor cyclopropane family and, therefore, are promising substrates for the preparation of chromene-based fine chemicals. The method, based on the acetic acid-induced intramolecular transester...

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Autores principales: Ivanova, Olga A., Andronov, Vladimir A., Levina, Irina I., Chagarovskiy, Alexey O., Voskressensky, Leonid G., Trushkov, Igor V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337311/
https://www.ncbi.nlm.nih.gov/pubmed/30586901
http://dx.doi.org/10.3390/molecules24010057
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author Ivanova, Olga A.
Andronov, Vladimir A.
Levina, Irina I.
Chagarovskiy, Alexey O.
Voskressensky, Leonid G.
Trushkov, Igor V.
author_facet Ivanova, Olga A.
Andronov, Vladimir A.
Levina, Irina I.
Chagarovskiy, Alexey O.
Voskressensky, Leonid G.
Trushkov, Igor V.
author_sort Ivanova, Olga A.
collection PubMed
description A simple method has been developed for the synthesis of cyclopropa[c]coumarins, which belong to the donor-acceptor cyclopropane family and, therefore, are promising substrates for the preparation of chromene-based fine chemicals. The method, based on the acetic acid-induced intramolecular transesterification of 2-arylcyclopropane-1,1-dicarboxylates, was found to be efficient for substrates containing hydroxy group directly attached to the aromatic ring.
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spelling pubmed-63373112019-01-25 Convenient Synthesis of Functionalized Cyclopropa[c]coumarin-1a-carboxylates Ivanova, Olga A. Andronov, Vladimir A. Levina, Irina I. Chagarovskiy, Alexey O. Voskressensky, Leonid G. Trushkov, Igor V. Molecules Communication A simple method has been developed for the synthesis of cyclopropa[c]coumarins, which belong to the donor-acceptor cyclopropane family and, therefore, are promising substrates for the preparation of chromene-based fine chemicals. The method, based on the acetic acid-induced intramolecular transesterification of 2-arylcyclopropane-1,1-dicarboxylates, was found to be efficient for substrates containing hydroxy group directly attached to the aromatic ring. MDPI 2018-12-24 /pmc/articles/PMC6337311/ /pubmed/30586901 http://dx.doi.org/10.3390/molecules24010057 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Ivanova, Olga A.
Andronov, Vladimir A.
Levina, Irina I.
Chagarovskiy, Alexey O.
Voskressensky, Leonid G.
Trushkov, Igor V.
Convenient Synthesis of Functionalized Cyclopropa[c]coumarin-1a-carboxylates
title Convenient Synthesis of Functionalized Cyclopropa[c]coumarin-1a-carboxylates
title_full Convenient Synthesis of Functionalized Cyclopropa[c]coumarin-1a-carboxylates
title_fullStr Convenient Synthesis of Functionalized Cyclopropa[c]coumarin-1a-carboxylates
title_full_unstemmed Convenient Synthesis of Functionalized Cyclopropa[c]coumarin-1a-carboxylates
title_short Convenient Synthesis of Functionalized Cyclopropa[c]coumarin-1a-carboxylates
title_sort convenient synthesis of functionalized cyclopropa[c]coumarin-1a-carboxylates
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337311/
https://www.ncbi.nlm.nih.gov/pubmed/30586901
http://dx.doi.org/10.3390/molecules24010057
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