Role of HDAC3-miRNA-CAGE Network in Anti-Cancer Drug-Resistance

Histone modification is associated with resistance to anti-cancer drugs. Epigenetic modifications of histones can regulate resistance to anti-cancer drugs. It has been reported that histone deacetylase 3 (HDAC3) regulates responses to anti-cancer drugs, angiogenic potential, and tumorigenic potentia...

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Autores principales: Kwon, Yoojung, Kim, Youngmi, Jung, Hyun Suk, Jeoung, Dooil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337380/
https://www.ncbi.nlm.nih.gov/pubmed/30583572
http://dx.doi.org/10.3390/ijms20010051
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author Kwon, Yoojung
Kim, Youngmi
Jung, Hyun Suk
Jeoung, Dooil
author_facet Kwon, Yoojung
Kim, Youngmi
Jung, Hyun Suk
Jeoung, Dooil
author_sort Kwon, Yoojung
collection PubMed
description Histone modification is associated with resistance to anti-cancer drugs. Epigenetic modifications of histones can regulate resistance to anti-cancer drugs. It has been reported that histone deacetylase 3 (HDAC3) regulates responses to anti-cancer drugs, angiogenic potential, and tumorigenic potential of cancer cells in association with cancer-associated genes (CAGE), and in particular, a cancer/testis antigen gene. In this paper, we report the roles of microRNAs that regulate the expression of HDAC3 and CAGE involved in resistance to anti-cancer drugs and associated mechanisms. In this review, roles of HDAC3-miRNAs-CAGE molecular networks in resistance to anti-cancer drugs, and the relevance of HDAC3 as a target for developing anti-cancer drugs are discussed.
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spelling pubmed-63373802019-01-22 Role of HDAC3-miRNA-CAGE Network in Anti-Cancer Drug-Resistance Kwon, Yoojung Kim, Youngmi Jung, Hyun Suk Jeoung, Dooil Int J Mol Sci Review Histone modification is associated with resistance to anti-cancer drugs. Epigenetic modifications of histones can regulate resistance to anti-cancer drugs. It has been reported that histone deacetylase 3 (HDAC3) regulates responses to anti-cancer drugs, angiogenic potential, and tumorigenic potential of cancer cells in association with cancer-associated genes (CAGE), and in particular, a cancer/testis antigen gene. In this paper, we report the roles of microRNAs that regulate the expression of HDAC3 and CAGE involved in resistance to anti-cancer drugs and associated mechanisms. In this review, roles of HDAC3-miRNAs-CAGE molecular networks in resistance to anti-cancer drugs, and the relevance of HDAC3 as a target for developing anti-cancer drugs are discussed. MDPI 2018-12-23 /pmc/articles/PMC6337380/ /pubmed/30583572 http://dx.doi.org/10.3390/ijms20010051 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kwon, Yoojung
Kim, Youngmi
Jung, Hyun Suk
Jeoung, Dooil
Role of HDAC3-miRNA-CAGE Network in Anti-Cancer Drug-Resistance
title Role of HDAC3-miRNA-CAGE Network in Anti-Cancer Drug-Resistance
title_full Role of HDAC3-miRNA-CAGE Network in Anti-Cancer Drug-Resistance
title_fullStr Role of HDAC3-miRNA-CAGE Network in Anti-Cancer Drug-Resistance
title_full_unstemmed Role of HDAC3-miRNA-CAGE Network in Anti-Cancer Drug-Resistance
title_short Role of HDAC3-miRNA-CAGE Network in Anti-Cancer Drug-Resistance
title_sort role of hdac3-mirna-cage network in anti-cancer drug-resistance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337380/
https://www.ncbi.nlm.nih.gov/pubmed/30583572
http://dx.doi.org/10.3390/ijms20010051
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AT junghyunsuk roleofhdac3mirnacagenetworkinanticancerdrugresistance
AT jeoungdooil roleofhdac3mirnacagenetworkinanticancerdrugresistance

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