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Discovery of Potent Inhibitors for the Large Neutral Amino Acid Transporter 1 (LAT1) by Structure-Based Methods

The large neutral amino acid transporter 1 (LAT1) is a promising anticancer target that is required for the cellular uptake of essential amino acids that serve as building blocks for cancer growth and proliferation. Here, we report a structure-based approach to identify chemically diverse and potent...

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Detalles Bibliográficos
Autores principales:	Singh, Natesh, Scalise, Mariafrancesca, Galluccio, Michele, Wieder, Marcus, Seidel, Thomas, Langer, Thierry, Indiveri, Cesare, Ecker, Gerhard F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337383/ https://www.ncbi.nlm.nih.gov/pubmed/30577601 http://dx.doi.org/10.3390/ijms20010027

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