Recent Advances in the Addition of Amide/Sulfonamide Bonds to Alkynes

The addition of amide/sulfonamide bonds to alkynes is not only one of the most important strategies for the direct functionalization of carbon–carbon triple bonds, but also a powerful tool for the downstream transformations of amides/sulfonamides. The present review provides a comprehensive summary...

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Detalles Bibliográficos
Autores principales: Zhao, Fei, Li, Pinyi, Liu, Xiaoyan, Jia, Xiuwen, Wang, Jiang, Liu, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337386/
https://www.ncbi.nlm.nih.gov/pubmed/30621120
http://dx.doi.org/10.3390/molecules24010164
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author Zhao, Fei
Li, Pinyi
Liu, Xiaoyan
Jia, Xiuwen
Wang, Jiang
Liu, Hong
author_facet Zhao, Fei
Li, Pinyi
Liu, Xiaoyan
Jia, Xiuwen
Wang, Jiang
Liu, Hong
author_sort Zhao, Fei
collection PubMed
description The addition of amide/sulfonamide bonds to alkynes is not only one of the most important strategies for the direct functionalization of carbon–carbon triple bonds, but also a powerful tool for the downstream transformations of amides/sulfonamides. The present review provides a comprehensive summary of amide/sulfonamide bond addition to alkynes, including direct and metal-free aminoacylation, based-promoted aminoacylation, transition-metal-catalyzed aminoacylation, organocatalytic aminoacylation and transition-metal-catalyzed aminosulfonylation of alkynes up to December 2018. The reaction conditions, regio- and stereoselectivities, and mechanisms are discussed and summarized in detail.
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spelling pubmed-63373862019-01-25 Recent Advances in the Addition of Amide/Sulfonamide Bonds to Alkynes Zhao, Fei Li, Pinyi Liu, Xiaoyan Jia, Xiuwen Wang, Jiang Liu, Hong Molecules Review The addition of amide/sulfonamide bonds to alkynes is not only one of the most important strategies for the direct functionalization of carbon–carbon triple bonds, but also a powerful tool for the downstream transformations of amides/sulfonamides. The present review provides a comprehensive summary of amide/sulfonamide bond addition to alkynes, including direct and metal-free aminoacylation, based-promoted aminoacylation, transition-metal-catalyzed aminoacylation, organocatalytic aminoacylation and transition-metal-catalyzed aminosulfonylation of alkynes up to December 2018. The reaction conditions, regio- and stereoselectivities, and mechanisms are discussed and summarized in detail. MDPI 2019-01-04 /pmc/articles/PMC6337386/ /pubmed/30621120 http://dx.doi.org/10.3390/molecules24010164 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhao, Fei
Li, Pinyi
Liu, Xiaoyan
Jia, Xiuwen
Wang, Jiang
Liu, Hong
Recent Advances in the Addition of Amide/Sulfonamide Bonds to Alkynes
title Recent Advances in the Addition of Amide/Sulfonamide Bonds to Alkynes
title_full Recent Advances in the Addition of Amide/Sulfonamide Bonds to Alkynes
title_fullStr Recent Advances in the Addition of Amide/Sulfonamide Bonds to Alkynes
title_full_unstemmed Recent Advances in the Addition of Amide/Sulfonamide Bonds to Alkynes
title_short Recent Advances in the Addition of Amide/Sulfonamide Bonds to Alkynes
title_sort recent advances in the addition of amide/sulfonamide bonds to alkynes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337386/
https://www.ncbi.nlm.nih.gov/pubmed/30621120
http://dx.doi.org/10.3390/molecules24010164
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