5-Azacitidine Exerts Prolonged Pro-Apoptotic Effects and Overcomes Cisplatin-Resistance in Non-Seminomatous Germ Cell Tumor Cells

Despite high cure rates, about 20% of patients with advanced germ cell tumors (GCTs) fail cisplatin-based chemotherapy. High levels of DNA methylation have been identified in GCTs and linked to cisplatin resistance. Here, we examined the effects of DNA hypomethylating 5-azacitidine (5-aza) on two em...

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Detalles Bibliográficos
Autores principales: Oing, Christoph, Verem, Izudin, Mansour, Wael Y., Bokemeyer, Carsten, Dyshlovoy, Sergey, Honecker, Friedemann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337423/
https://www.ncbi.nlm.nih.gov/pubmed/30577584
http://dx.doi.org/10.3390/ijms20010021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337423/
https://www.ncbi.nlm.nih.gov/pubmed/30577584
http://dx.doi.org/10.3390/ijms20010021

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