Cargando…

Cdc42: A Novel Regulator of Insulin Secretion and Diabetes-Associated Diseases

Cdc42, a member of the Rho GTPases family, is involved in the regulation of several cellular functions including cell cycle progression, survival, transcription, actin cytoskeleton organization and membrane trafficking. Diabetes is a chronic and metabolic disease, characterized as glycometabolism di...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Qi-Yuan, Lai, Xing-Ning, Qian, Xian-Ling, Lv, Lin-Chen, Li, Jun, Duan, Jing, Xiao, Xing-Hua, Xiong, Li-Xia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337499/ https://www.ncbi.nlm.nih.gov/pubmed/30621321 http://dx.doi.org/10.3390/ijms20010179

Ejemplares similares

Cdc42 Promotes ADSC-Derived IPC Induction, Proliferation, And Insulin Secretion Via Wnt/β-Catenin Signaling
por: Xiao, Xing-Hua, et al.
Publicado: (2019)

miR-29a Negatively Affects Glucose-Stimulated Insulin Secretion and MIN6 Cell Proliferation via Cdc42/β-Catenin Signaling
por: Duan, Jing, et al.
Publicado: (2019)

Cdc42 upregulation under high glucose induces podocyte apoptosis and impairs β-cell insulin secretion
por: Jiang, Shan, et al.
Publicado: (2022)

Regulating Cdc42 and Its Signaling Pathways in Cancer: Small Molecules and MicroRNA as New Treatment Candidates
por: Xiao, Xing-Hua, et al.
Publicado: (2018)

Focus on Cdc42 in Breast Cancer: New Insights, Target Therapy Development and Non-Coding RNAs
por: Zhang, Yu, et al.
Publicado: (2019)

CDC42-interacting protein 4 promotes metastasis of nasopharyngeal carcinoma by mediating invadopodia formation and activating EGFR signaling
por: Meng, Dong-Fang, et al.
Publicado: (2017)

The Borg family of Cdc42 effector proteins Cdc42EP1–5
por: Farrugia, Aaron J., et al.
Publicado: (2016)

Cdc42 regulates Cdc42EP3 function in cancer-associated fibroblasts
por: Farrugia, Aaron J., et al.
Publicado: (2016)

Erratum to: CDC42-interacting protein 4 promotes metastasis of nasopharyngeal carcinoma by mediating invadopodia formation and activating EGFR signaling
por: Meng, Dong-Fang, et al.
Publicado: (2017)

Cdc42 turns the spindle
por: Leslie, Mitch
Publicado: (2008)

The first buds of Cdc42
por: Short, Ben
Publicado: (2015)

Cdc42 Effector Protein 3 Interacts With Cdc42 in Regulating Xenopus Somite Segmentation
por: Kho, Mary, et al.
Publicado: (2019)

Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis
por: Duan, Xin, et al.
Publicado: (2021)

Use of First-phase Insulin Secretion in Early Diagnosis of Thyroid Diabetes and Type 2 Diabetes Mellitus
por: Meng, Li-Heng, et al.
Publicado: (2017)

Bacterial infection promotes tumorigenesis of colorectal cancer via regulating CDC42 acetylation
por: Wang, Dan-Ni, et al.
Publicado: (2023)

The Cdc42 effectors Gic1 and Gic2 regulate polarized post-Golgi secretion
por: Liu, Ying, et al.
Publicado: (2019)

The Cdc42 GAP Rga6 promotes monopolar outgrowth of spores
por: Wei, Wenfan, et al.
Publicado: (2022)

Spatial analysis of Cdc42 activity reveals a role for plasma membrane–associated Cdc42 in centrosome regulation
por: Herrington, Kari A., et al.
Publicado: (2017)

Advances in the study of CDC42 in the female reproductive system
por: Mei, Qiaojuan, et al.
Publicado: (2021)

Nucleocytoplasmic Shuttling of the Cdc42p Exchange Factor Cdc24p
por: Nern, Aljoscha, et al.
Publicado: (2000)

A Role for Cdc42 in Macrophage Chemotaxis
por: Allen, William E., et al.
Publicado: (1998)

Cdc42 and Tinman march to the same beat
por: Short, Ben
Publicado: (2011)

Ubiquitin-dependent regulation of Cdc42 by XIAP
por: Murali, Arun, et al.
Publicado: (2017)

Infantile Myelofibrosis and Myeloproliferation with CDC42 Dysfunction
por: Verboon, Jeffrey M., et al.
Publicado: (2020)

Molecular subversion of Cdc42 signalling in cancer
por: Murphy, Natasha P., et al.
Publicado: (2021)

Progress in the therapeutic inhibition of Cdc42 signalling
por: Murphy, Natasha P., et al.
Publicado: (2021)

Activation of Cdc42 by trans interactions of the cell adhesion molecules nectins through c-Src and Cdc42-GEF FRG
por: Fukuhara, Tatsuro, et al.
Publicado: (2004)

Inhibition of Cdc42 is essential for Mig-6 suppression of cell migration induced by EGF
por: Jiang, Xinni, et al.
Publicado: (2016)

Involvement of Activated Cdc42 Kinase1 in Colitis and Colorectal Neoplasms
por: Lv, Chaolan, et al.
Publicado: (2016)

Rational Targeting of Cdc42 Overcomes Drug Resistance of Multiple Myeloma
por: Nguyen, Phuong, et al.
Publicado: (2019)

Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity
por: Kalim, Khalid W, et al.
Publicado: (2022)

Cloning and Differential Expression Analyses of Cdc42 from Sheep
por: Yang, Yong-Jie, et al.
Publicado: (2018)

Identification of Kic1p and Cdc42p as Novel Targets to Engineer Yeast Acetic Acid Stress Tolerance
por: Chen, Hong-Qi, et al.
Publicado: (2022)

Regulation and functional significance of CDC42 alternative splicing in ovarian cancer
por: He, Xiaolong, et al.
Publicado: (2015)

Limiting lumens: a new role for Cdc42
por: Lechler, Terry
Publicado: (2008)

Cdc42 regulation of polarized traffic in fission yeast
por: Estravis, Miguel, et al.
Publicado: (2012)

The evolutionary history of effectors downstream of Cdc42 and Rac
por: Cotteret, Sophie, et al.
Publicado: (2002)

Cdc42 interacts with the exocyst complex to promote phagocytosis
por: Mohammadi, Sina, et al.
Publicado: (2013)

Cdc42 helps cells take bigger bites
por: Leslie, Mitch
Publicado: (2013)

Budding yeast do the Cdc42 two-step
por: Short, Ben
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_and93l5h463ug4faq1uug2mqm0