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Therapeutic Inhibition of Myc in Cancer. Structural Bases and Computer-Aided Drug Discovery Approaches

Myc (avian myelocytomatosis viral oncogene homolog) represents one of the most sought after drug targets in cancer. Myc transcription factor is an essential regulator of cell growth, but in most cancers it is overexpressed and associated with treatment-resistance and lethal outcomes. Over 40 years o...

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Detalles Bibliográficos
Autores principales:	Carabet, Lavinia A., Rennie, Paul S., Cherkasov, Artem
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337544/ https://www.ncbi.nlm.nih.gov/pubmed/30597997 http://dx.doi.org/10.3390/ijms20010120

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