Cargando…

LAIPT: Lysine Acetylation Site Identification with Polynomial Tree

Post-translational modification plays a key role in the field of biology. Experimental identification methods are time-consuming and expensive. Therefore, computational methods to deal with such issues overcome these shortcomings and limitations. In this article, we propose a lysine acetylation site...

Descripción completa

Detalles Bibliográficos
Autores principales: Bao, Wenzheng, Yang, Bin, Li, Zhengwei, Zhou, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337602/
https://www.ncbi.nlm.nih.gov/pubmed/30597947
http://dx.doi.org/10.3390/ijms20010113
_version_ 1783388293037031424
author Bao, Wenzheng
Yang, Bin
Li, Zhengwei
Zhou, Yong
author_facet Bao, Wenzheng
Yang, Bin
Li, Zhengwei
Zhou, Yong
author_sort Bao, Wenzheng
collection PubMed
description Post-translational modification plays a key role in the field of biology. Experimental identification methods are time-consuming and expensive. Therefore, computational methods to deal with such issues overcome these shortcomings and limitations. In this article, we propose a lysine acetylation site identification with polynomial tree method (LAIPT), making use of the polynomial style to demonstrate amino-acid residue relationships in peptide segments. This polynomial style was enriched by the physical and chemical properties of amino-acid residues. Then, these reconstructed features were input into the employed classification model, named the flexible neural tree. Finally, some effect evaluation measurements were employed to test the model’s performance.
format Online
Article
Text
id pubmed-6337602
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-63376022019-01-22 LAIPT: Lysine Acetylation Site Identification with Polynomial Tree Bao, Wenzheng Yang, Bin Li, Zhengwei Zhou, Yong Int J Mol Sci Article Post-translational modification plays a key role in the field of biology. Experimental identification methods are time-consuming and expensive. Therefore, computational methods to deal with such issues overcome these shortcomings and limitations. In this article, we propose a lysine acetylation site identification with polynomial tree method (LAIPT), making use of the polynomial style to demonstrate amino-acid residue relationships in peptide segments. This polynomial style was enriched by the physical and chemical properties of amino-acid residues. Then, these reconstructed features were input into the employed classification model, named the flexible neural tree. Finally, some effect evaluation measurements were employed to test the model’s performance. MDPI 2018-12-29 /pmc/articles/PMC6337602/ /pubmed/30597947 http://dx.doi.org/10.3390/ijms20010113 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bao, Wenzheng
Yang, Bin
Li, Zhengwei
Zhou, Yong
LAIPT: Lysine Acetylation Site Identification with Polynomial Tree
title LAIPT: Lysine Acetylation Site Identification with Polynomial Tree
title_full LAIPT: Lysine Acetylation Site Identification with Polynomial Tree
title_fullStr LAIPT: Lysine Acetylation Site Identification with Polynomial Tree
title_full_unstemmed LAIPT: Lysine Acetylation Site Identification with Polynomial Tree
title_short LAIPT: Lysine Acetylation Site Identification with Polynomial Tree
title_sort laipt: lysine acetylation site identification with polynomial tree
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337602/
https://www.ncbi.nlm.nih.gov/pubmed/30597947
http://dx.doi.org/10.3390/ijms20010113
work_keys_str_mv AT baowenzheng laiptlysineacetylationsiteidentificationwithpolynomialtree
AT yangbin laiptlysineacetylationsiteidentificationwithpolynomialtree
AT lizhengwei laiptlysineacetylationsiteidentificationwithpolynomialtree
AT zhouyong laiptlysineacetylationsiteidentificationwithpolynomialtree