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LAIPT: Lysine Acetylation Site Identification with Polynomial Tree
Post-translational modification plays a key role in the field of biology. Experimental identification methods are time-consuming and expensive. Therefore, computational methods to deal with such issues overcome these shortcomings and limitations. In this article, we propose a lysine acetylation site...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337602/ https://www.ncbi.nlm.nih.gov/pubmed/30597947 http://dx.doi.org/10.3390/ijms20010113 |
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author | Bao, Wenzheng Yang, Bin Li, Zhengwei Zhou, Yong |
author_facet | Bao, Wenzheng Yang, Bin Li, Zhengwei Zhou, Yong |
author_sort | Bao, Wenzheng |
collection | PubMed |
description | Post-translational modification plays a key role in the field of biology. Experimental identification methods are time-consuming and expensive. Therefore, computational methods to deal with such issues overcome these shortcomings and limitations. In this article, we propose a lysine acetylation site identification with polynomial tree method (LAIPT), making use of the polynomial style to demonstrate amino-acid residue relationships in peptide segments. This polynomial style was enriched by the physical and chemical properties of amino-acid residues. Then, these reconstructed features were input into the employed classification model, named the flexible neural tree. Finally, some effect evaluation measurements were employed to test the model’s performance. |
format | Online Article Text |
id | pubmed-6337602 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63376022019-01-22 LAIPT: Lysine Acetylation Site Identification with Polynomial Tree Bao, Wenzheng Yang, Bin Li, Zhengwei Zhou, Yong Int J Mol Sci Article Post-translational modification plays a key role in the field of biology. Experimental identification methods are time-consuming and expensive. Therefore, computational methods to deal with such issues overcome these shortcomings and limitations. In this article, we propose a lysine acetylation site identification with polynomial tree method (LAIPT), making use of the polynomial style to demonstrate amino-acid residue relationships in peptide segments. This polynomial style was enriched by the physical and chemical properties of amino-acid residues. Then, these reconstructed features were input into the employed classification model, named the flexible neural tree. Finally, some effect evaluation measurements were employed to test the model’s performance. MDPI 2018-12-29 /pmc/articles/PMC6337602/ /pubmed/30597947 http://dx.doi.org/10.3390/ijms20010113 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bao, Wenzheng Yang, Bin Li, Zhengwei Zhou, Yong LAIPT: Lysine Acetylation Site Identification with Polynomial Tree |
title | LAIPT: Lysine Acetylation Site Identification with Polynomial Tree |
title_full | LAIPT: Lysine Acetylation Site Identification with Polynomial Tree |
title_fullStr | LAIPT: Lysine Acetylation Site Identification with Polynomial Tree |
title_full_unstemmed | LAIPT: Lysine Acetylation Site Identification with Polynomial Tree |
title_short | LAIPT: Lysine Acetylation Site Identification with Polynomial Tree |
title_sort | laipt: lysine acetylation site identification with polynomial tree |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337602/ https://www.ncbi.nlm.nih.gov/pubmed/30597947 http://dx.doi.org/10.3390/ijms20010113 |
work_keys_str_mv | AT baowenzheng laiptlysineacetylationsiteidentificationwithpolynomialtree AT yangbin laiptlysineacetylationsiteidentificationwithpolynomialtree AT lizhengwei laiptlysineacetylationsiteidentificationwithpolynomialtree AT zhouyong laiptlysineacetylationsiteidentificationwithpolynomialtree |