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Lung Macrophages: Multifunctional Regulator Cells for Metastatic Cells
Metastasis is responsible for most of the cancer-associated deaths and proceeds through multiple steps. Several lines of evidence have established an indispensable involvement of macrophages present at the primary tumor sites in various steps of metastasis, from primary tumor growth to its intravasa...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337639/ https://www.ncbi.nlm.nih.gov/pubmed/30597969 http://dx.doi.org/10.3390/ijms20010116 |
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author | Mukaida, Naofumi Nosaka, Takuto Nakamoto, Yasunari Baba, Tomohisa |
author_facet | Mukaida, Naofumi Nosaka, Takuto Nakamoto, Yasunari Baba, Tomohisa |
author_sort | Mukaida, Naofumi |
collection | PubMed |
description | Metastasis is responsible for most of the cancer-associated deaths and proceeds through multiple steps. Several lines of evidence have established an indispensable involvement of macrophages present at the primary tumor sites in various steps of metastasis, from primary tumor growth to its intravasation into circulation. The lungs encompass a large, dense vascular area and, therefore, are vulnerable to metastasis, particularly, hematogenous ones arising from various types of neoplasms. Lung tissues constitutively contain several types of tissue-resident macrophages and circulating monocytes to counteract potentially harmful exogenous materials, which directly reach through the airway. Recent advances have provided an insight into the ontogenetic, phenotypic, and functional heterogeneity of these lung macrophage and monocyte populations, under resting and inflammatory conditions. In this review, we discuss the ontogeny, trafficking dynamics, and functions of these pulmonary macrophages and monocytes and their potential roles in lung metastasis and measures to combat lung metastasis by targeting these populations. |
format | Online Article Text |
id | pubmed-6337639 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63376392019-01-22 Lung Macrophages: Multifunctional Regulator Cells for Metastatic Cells Mukaida, Naofumi Nosaka, Takuto Nakamoto, Yasunari Baba, Tomohisa Int J Mol Sci Review Metastasis is responsible for most of the cancer-associated deaths and proceeds through multiple steps. Several lines of evidence have established an indispensable involvement of macrophages present at the primary tumor sites in various steps of metastasis, from primary tumor growth to its intravasation into circulation. The lungs encompass a large, dense vascular area and, therefore, are vulnerable to metastasis, particularly, hematogenous ones arising from various types of neoplasms. Lung tissues constitutively contain several types of tissue-resident macrophages and circulating monocytes to counteract potentially harmful exogenous materials, which directly reach through the airway. Recent advances have provided an insight into the ontogenetic, phenotypic, and functional heterogeneity of these lung macrophage and monocyte populations, under resting and inflammatory conditions. In this review, we discuss the ontogeny, trafficking dynamics, and functions of these pulmonary macrophages and monocytes and their potential roles in lung metastasis and measures to combat lung metastasis by targeting these populations. MDPI 2018-12-29 /pmc/articles/PMC6337639/ /pubmed/30597969 http://dx.doi.org/10.3390/ijms20010116 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mukaida, Naofumi Nosaka, Takuto Nakamoto, Yasunari Baba, Tomohisa Lung Macrophages: Multifunctional Regulator Cells for Metastatic Cells |
title | Lung Macrophages: Multifunctional Regulator Cells for Metastatic Cells |
title_full | Lung Macrophages: Multifunctional Regulator Cells for Metastatic Cells |
title_fullStr | Lung Macrophages: Multifunctional Regulator Cells for Metastatic Cells |
title_full_unstemmed | Lung Macrophages: Multifunctional Regulator Cells for Metastatic Cells |
title_short | Lung Macrophages: Multifunctional Regulator Cells for Metastatic Cells |
title_sort | lung macrophages: multifunctional regulator cells for metastatic cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337639/ https://www.ncbi.nlm.nih.gov/pubmed/30597969 http://dx.doi.org/10.3390/ijms20010116 |
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