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Loss of the adhesion G-protein coupled receptor ADGRF5 in mice induces airway inflammation and the expression of CCL2 in lung endothelial cells

BACKGROUND: Adhesion G-protein coupled receptor F5 (ADGRF5) was recently identified as an essential regulator of pulmonary surfactant homeostasis in alveolar type II cells. We previously showed that in addition to abnormal surfactant accumulation, Adgrf5-deficient (Adgrf5(−/−)) mice exhibit emphysem...

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Detalles Bibliográficos
Autores principales:	Kubo, Fumimasa, Ariestanti, Donna Maretta, Oki, Souta, Fukuzawa, Taku, Demizu, Ryotaro, Sato, Tomoya, Sabirin, Rahmaningsih Mara, Hirose, Shigehisa, Nakamura, Nobuhiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337809/ https://www.ncbi.nlm.nih.gov/pubmed/30654796 http://dx.doi.org/10.1186/s12931-019-0973-6

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