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Malignant peripheral nerve sheath tumor of the transverse colon with peritoneal metastasis: a case report

BACKGROUND: Malignant peripheral nerve sheath tumors are malignant tumors arising from a peripheral nerve or displaying nerve sheath differentiation. Gastrointestinal malignant peripheral nerve sheath tumors are rare and malignant peripheral nerve sheath tumor of the colon is even rarer. To date, on...

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Autores principales: Rawal, Gireesha, Zaheer, Sufian, Ahluwalia, Charanjeet, Dhawan, Indrani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337829/
https://www.ncbi.nlm.nih.gov/pubmed/30654838
http://dx.doi.org/10.1186/s13256-018-1896-4
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author Rawal, Gireesha
Zaheer, Sufian
Ahluwalia, Charanjeet
Dhawan, Indrani
author_facet Rawal, Gireesha
Zaheer, Sufian
Ahluwalia, Charanjeet
Dhawan, Indrani
author_sort Rawal, Gireesha
collection PubMed
description BACKGROUND: Malignant peripheral nerve sheath tumors are malignant tumors arising from a peripheral nerve or displaying nerve sheath differentiation. Gastrointestinal malignant peripheral nerve sheath tumors are rare and malignant peripheral nerve sheath tumor of the colon is even rarer. To date, only five cases have been reported as malignant peripheral nerve sheath tumor arising in the colon. This is probably the first case report of malignant peripheral nerve sheath tumor of the transverse colon associated with peritoneal metastasis. CASE PRESENTATION: A 25-year-old Indian man presented with a large abdominal mass. A computed tomography scan revealed a large 18 cm-sized mass in his transverse colon, suggestive of gastrointestinal stromal tumor. A wide local excision was performed. Histopathology showed sheets and fascicles of elongated to spindle-shaped tumor cells showing a moderate degree of pleomorphism and atypia. Based on morphology and immunohistochemistry, a final diagnosis of malignant peripheral nerve sheath tumor of the transverse colon was given. A peritoneal metastatic tumor deposit was identified grossly and confirmed on histopathology. CONCLUSION: This is a rare case report discussing the detailed diagnostic approach along with an extensive review of the literature for malignant peripheral nerve sheath tumor arising in the colon. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13256-018-1896-4) contains supplementary material, which is available to authorized users.
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spelling pubmed-63378292019-01-23 Malignant peripheral nerve sheath tumor of the transverse colon with peritoneal metastasis: a case report Rawal, Gireesha Zaheer, Sufian Ahluwalia, Charanjeet Dhawan, Indrani J Med Case Rep Case Report BACKGROUND: Malignant peripheral nerve sheath tumors are malignant tumors arising from a peripheral nerve or displaying nerve sheath differentiation. Gastrointestinal malignant peripheral nerve sheath tumors are rare and malignant peripheral nerve sheath tumor of the colon is even rarer. To date, only five cases have been reported as malignant peripheral nerve sheath tumor arising in the colon. This is probably the first case report of malignant peripheral nerve sheath tumor of the transverse colon associated with peritoneal metastasis. CASE PRESENTATION: A 25-year-old Indian man presented with a large abdominal mass. A computed tomography scan revealed a large 18 cm-sized mass in his transverse colon, suggestive of gastrointestinal stromal tumor. A wide local excision was performed. Histopathology showed sheets and fascicles of elongated to spindle-shaped tumor cells showing a moderate degree of pleomorphism and atypia. Based on morphology and immunohistochemistry, a final diagnosis of malignant peripheral nerve sheath tumor of the transverse colon was given. A peritoneal metastatic tumor deposit was identified grossly and confirmed on histopathology. CONCLUSION: This is a rare case report discussing the detailed diagnostic approach along with an extensive review of the literature for malignant peripheral nerve sheath tumor arising in the colon. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13256-018-1896-4) contains supplementary material, which is available to authorized users. BioMed Central 2019-01-18 /pmc/articles/PMC6337829/ /pubmed/30654838 http://dx.doi.org/10.1186/s13256-018-1896-4 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Rawal, Gireesha
Zaheer, Sufian
Ahluwalia, Charanjeet
Dhawan, Indrani
Malignant peripheral nerve sheath tumor of the transverse colon with peritoneal metastasis: a case report
title Malignant peripheral nerve sheath tumor of the transverse colon with peritoneal metastasis: a case report
title_full Malignant peripheral nerve sheath tumor of the transverse colon with peritoneal metastasis: a case report
title_fullStr Malignant peripheral nerve sheath tumor of the transverse colon with peritoneal metastasis: a case report
title_full_unstemmed Malignant peripheral nerve sheath tumor of the transverse colon with peritoneal metastasis: a case report
title_short Malignant peripheral nerve sheath tumor of the transverse colon with peritoneal metastasis: a case report
title_sort malignant peripheral nerve sheath tumor of the transverse colon with peritoneal metastasis: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337829/
https://www.ncbi.nlm.nih.gov/pubmed/30654838
http://dx.doi.org/10.1186/s13256-018-1896-4
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