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Irisin interaction with adipose tissue secretions by exercise training and flaxseed oil supplement
BACKGROUND: Previous studies have shown that physical training and natural diet able to change the expression and concentration of peptides and proteins. Myokines and adipokines play an important role in metabolism and metabolic syndrome. Therefore, the purpose of the present study was to investigat...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337839/ https://www.ncbi.nlm.nih.gov/pubmed/30654813 http://dx.doi.org/10.1186/s12944-019-0960-4 |
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author | Shirvani, Hossein Rahmati-Ahmadabad, Saleh |
author_facet | Shirvani, Hossein Rahmati-Ahmadabad, Saleh |
author_sort | Shirvani, Hossein |
collection | PubMed |
description | BACKGROUND: Previous studies have shown that physical training and natural diet able to change the expression and concentration of peptides and proteins. Myokines and adipokines play an important role in metabolism and metabolic syndrome. Therefore, the purpose of the present study was to investigate the effect of high-intensity interval training (HIIT) and supplementation of flaxseed oil on plasma irisin, nesfatin-1 and resistin in male rats. METHODS: Forty adult male rats were randomly divided into four groups (ten in each group) including Control-Saline (CS), Training-Saline (TS), Control-FlaxOil supplement (CO), and Training-FlaxOil supplement (TO). The training groups performed for 10 weeks and 5 sessions each week, interval training with 90–95% VO2max on rodent treadmill, and supplement groups received flaxseed oil (300 mg / kg). Five days after the last training session, rats were sacrificed. Blood samples were taken from the heart and plasma was evaluated. RESULTS: Exercise Training significantly increased plasma levels of irisin (P = 0.019), nesfatin-1 (P = 0.01), and decreased resistin (P = 0.01). Flaxseed oil significantly reduced plasma resistin levels (P = 0.02). Plasma irisin levels in the supplementation group were higher than all groups (P = 0.041). CONCLUSION: There was a significant positive correlation between plasma levels of irisin with nesfatin-1 and negative correlation with resistin. HIIT program with flaxseed oil as a modality can create a metabolic crosstalk between skeletal muscle and adipose tissues and have health benefits. |
format | Online Article Text |
id | pubmed-6337839 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-63378392019-01-23 Irisin interaction with adipose tissue secretions by exercise training and flaxseed oil supplement Shirvani, Hossein Rahmati-Ahmadabad, Saleh Lipids Health Dis Research BACKGROUND: Previous studies have shown that physical training and natural diet able to change the expression and concentration of peptides and proteins. Myokines and adipokines play an important role in metabolism and metabolic syndrome. Therefore, the purpose of the present study was to investigate the effect of high-intensity interval training (HIIT) and supplementation of flaxseed oil on plasma irisin, nesfatin-1 and resistin in male rats. METHODS: Forty adult male rats were randomly divided into four groups (ten in each group) including Control-Saline (CS), Training-Saline (TS), Control-FlaxOil supplement (CO), and Training-FlaxOil supplement (TO). The training groups performed for 10 weeks and 5 sessions each week, interval training with 90–95% VO2max on rodent treadmill, and supplement groups received flaxseed oil (300 mg / kg). Five days after the last training session, rats were sacrificed. Blood samples were taken from the heart and plasma was evaluated. RESULTS: Exercise Training significantly increased plasma levels of irisin (P = 0.019), nesfatin-1 (P = 0.01), and decreased resistin (P = 0.01). Flaxseed oil significantly reduced plasma resistin levels (P = 0.02). Plasma irisin levels in the supplementation group were higher than all groups (P = 0.041). CONCLUSION: There was a significant positive correlation between plasma levels of irisin with nesfatin-1 and negative correlation with resistin. HIIT program with flaxseed oil as a modality can create a metabolic crosstalk between skeletal muscle and adipose tissues and have health benefits. BioMed Central 2019-01-17 /pmc/articles/PMC6337839/ /pubmed/30654813 http://dx.doi.org/10.1186/s12944-019-0960-4 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Shirvani, Hossein Rahmati-Ahmadabad, Saleh Irisin interaction with adipose tissue secretions by exercise training and flaxseed oil supplement |
title | Irisin interaction with adipose tissue secretions by exercise training and flaxseed oil supplement |
title_full | Irisin interaction with adipose tissue secretions by exercise training and flaxseed oil supplement |
title_fullStr | Irisin interaction with adipose tissue secretions by exercise training and flaxseed oil supplement |
title_full_unstemmed | Irisin interaction with adipose tissue secretions by exercise training and flaxseed oil supplement |
title_short | Irisin interaction with adipose tissue secretions by exercise training and flaxseed oil supplement |
title_sort | irisin interaction with adipose tissue secretions by exercise training and flaxseed oil supplement |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337839/ https://www.ncbi.nlm.nih.gov/pubmed/30654813 http://dx.doi.org/10.1186/s12944-019-0960-4 |
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