Cargando…

ACVR1(R206H) FOP mutation alters mechanosensing and tissue stiffness during heterotopic ossification

An activating bone morphogenetic proteins (BMP) type I receptor ACVR1 (ACVR1(R206H)) mutation enhances BMP pathway signaling and causes the rare genetic disorder of heterotopic (extraskeletal) bone formation fibrodysplasia ossificans progressiva. Heterotopic ossification frequently occurs following...

Descripción completa

Detalles Bibliográficos
Autores principales:	Haupt, Julia, Stanley, Alexandra, McLeod, Claire M., Cosgrove, Brian D., Culbert, Andria L., Wang, Linda, Mourkioti, Foteini, Mauck, Robert L., Shore, Eileen M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337906/ https://www.ncbi.nlm.nih.gov/pubmed/30379592 http://dx.doi.org/10.1091/mbc.E18-05-0311

Ejemplares similares

Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1
por: Aykul, Senem, et al.
Publicado: (2022)

Comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity'
por: Pacifici, Maurizio, et al.
Publicado: (2019)

Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity
por: Lees-Shepard, John B, et al.
Publicado: (2018)

Response to comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity'
por: Goldhamer, David J, et al.
Publicado: (2019)

An anti-ACVR1 antibody exacerbates heterotopic ossification by fibro-adipogenic progenitors in fibrodysplasia ossificans progressiva mice
por: Lees-Shepard, John B., et al.
Publicado: (2022)

Functional Testing of Bone Morphogenetic Protein (BMP) Pathway Variants Identified on Whole‐Exome Sequencing in a Patient with Delayed‐Onset Fibrodysplasia Ossificans Progressiva (FOP) Using ACVR1(R206H) ‐Specific Human Cellular and Zebrafish Models
por: Wentworth, Kelly L., et al.
Publicado: (2022)

Pathogenic ACVR1(R206H) activation by Activin A‐induced receptor clustering and autophosphorylation
por: Ramachandran, Anassuya, et al.
Publicado: (2021)

Gnas Inactivation Alters Subcutaneous Tissues in Progression to Heterotopic Ossification
por: Brewer, Niambi, et al.
Publicado: (2021)

Overexpression of Wild‐Type ACVR1 in Fibrodysplasia Ossificans Progressiva Mice Rescues Perinatal Lethality and Inhibits Heterotopic Ossification
por: Yamamoto, Masakazu, et al.
Publicado: (2022)

Prophylactic treatment of rapamycin ameliorates naturally developing and episode -induced heterotopic ossification in mice expressing human mutant ACVR1
por: Maekawa, Hirotsugu, et al.
Publicado: (2020)

Recapitulation of pro-inflammatory signature of monocytes with ACVR1A mutation using FOP patient-derived iPSCs
por: Maekawa, Hirotsugu, et al.
Publicado: (2022)

Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification
por: Regard, Jean B., et al.
Publicado: (2013)

Heterotopic Ossification in the Gallbladder
por: Ahn, Jihyun, et al.
Publicado: (2017)

Limb specific Acvr1‐knockout during embryogenesis in mice exhibits great toe malformation as seen in Fibrodysplasia Ossificans Progressiva (FOP)
por: Hildebrand, Laura, et al.
Publicado: (2019)

Severe heterotopic ossification and stiffness after revision knee surgery for a periprosthetic fracture
por: Baroudi, Maher, et al.
Publicado: (2017)

Pulmonary Adenocarcinoma with Heterotopic Ossification
por: Kim, Gou Young, et al.
Publicado: (2009)

Blast injuries and heterotopic ossification
por: Alfieri, K. A., et al.
Publicado: (2012)

Heterotopic Ossification: An Unusual Presentation
por: Patil, Satish G., et al.
Publicado: (2012)

Heterotopic Ossification in Breast Prosthesis
por: Fradinho, Nuno, et al.
Publicado: (2015)

Heterotopic Ossification of Brachialis Muscle
por: George, Jacob
Publicado: (2005)

Heterotopic ossification of tendon and ligament
por: Zhang, Qiang, et al.
Publicado: (2020)

Contemporary perspectives on heterotopic ossification
por: Hwang, Charles D., et al.
Publicado: (2022)

Heterotopic Ossification in Hip Arthroscopy
por: Seijas, Roberto, et al.
Publicado: (2023)

Suppression of heterotopic ossification in fibrodysplasia ossificans progressiva using AAV gene delivery
por: Yang, Yeon-Suk, et al.
Publicado: (2022)

Modeling the ACVR1(R206H) mutation in human skeletal muscle stem cells
por: Barruet, Emilie, et al.
Publicado: (2021)

Rapid Progression of Heterotopic Ossification in Severe Variant of Fibrodysplasia Ossificans Progressiva with p.Arg258Gly in ACVR1: A Case Report and Review of Clinical Phenotypes
por: Hasegawa, Kosei, et al.
Publicado: (2022)

Prophylaxis of heterotopic ossification – an updated review
por: Baird, Evan O, et al.
Publicado: (2009)

Animal Models of Typical Heterotopic Ossification
por: Kan, Lixin, et al.
Publicado: (2011)

Heterotopic ossification after hip arthroscopy
por: Amar, Eyal, et al.
Publicado: (2015)

Heterotopic Ossification: A Comprehensive Review
por: Meyers, Carolyn, et al.
Publicado: (2019)

Heterotopic Ossification: Radiological and Pathological Review
por: Mujtaba, Bilal, et al.
Publicado: (2019)

Surgical Management of Shoulder Heterotopic Ossification
por: Hallock, Justin, et al.
Publicado: (2019)

Retinoid Agonists in the Targeting of Heterotopic Ossification
por: Pignolo, Robert J., et al.
Publicado: (2021)

New Strategies in Neurogenic Heterotopic Ossification
por: Ampadiotaki, Margarita-Michaela, et al.
Publicado: (2021)

Heterotopic Mesenteric Ossification With Trilineage Hematopoiesis
por: Martinbianco, Emily M, et al.
Publicado: (2022)

Fibrodysplasia ossificans progressiva mutant ACVR1 signals by multiple modalities in the developing zebrafish
por: Allen, Robyn S, et al.
Publicado: (2020)

Heterotopic Ossification in Orthopaedic and Trauma surgery: A Histopathological Ossification Score
por: Ohlmeier, M., et al.
Publicado: (2019)

Polypeptide Substrate Accessibility Hypothesis: Gain-of-Function R206H Mutation Allosterically Affects Activin Receptor-like Protein Kinase Activity
por: Groppe, Jay C., et al.
Publicado: (2023)

AAV-Mediated Targeting of the Activin A-ACVR1(R206H) Signaling in Fibrodysplasia Ossificans Progressiva
por: Yang, Yeon-Suk, et al.
Publicado: (2023)

Experimental model of heterotopic ossification in Wistar rats
por: Zotz, T.G.G., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_7vidmri35gm8l8edadcorp2aqt