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Disruption of Otoferlin Alters the Mode of Exocytosis at the Mouse Inner Hair Cell Ribbon Synapse

Sound encoding relies on Ca(2+)-mediated exocytosis at the ribbon synapse between cochlear inner hair cells (IHCs) and type I spiral ganglion neurons (SGNs). Otoferlin, a multi-C(2) domain protein, is proposed to regulate Ca(2+)-triggered exocytosis at this synapse, but the precise mechanisms of oto...

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Detalles Bibliográficos
Autores principales:	Takago, Hideki, Oshima-Takago, Tomoko, Moser, Tobias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338019/ https://www.ncbi.nlm.nih.gov/pubmed/30687007 http://dx.doi.org/10.3389/fnmol.2018.00492

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