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Enteropathogens: Tuning Their Gene Expression for Hassle-Free Survival

Enteropathogenic bacteria have been the cause of the majority of foodborne illnesses. Much of the research has been focused on elucidating the mechanisms by which these pathogens evade the host immune system. One of the ways in which they achieve the successful establishment of a niche in the gut mi...

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Autores principales: Chatterjee, Ritika, Shreenivas, Meghanashree M., Sunil, Rohith, Chakravortty, Dipshikha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338047/
https://www.ncbi.nlm.nih.gov/pubmed/30687282
http://dx.doi.org/10.3389/fmicb.2018.03303
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author Chatterjee, Ritika
Shreenivas, Meghanashree M.
Sunil, Rohith
Chakravortty, Dipshikha
author_facet Chatterjee, Ritika
Shreenivas, Meghanashree M.
Sunil, Rohith
Chakravortty, Dipshikha
author_sort Chatterjee, Ritika
collection PubMed
description Enteropathogenic bacteria have been the cause of the majority of foodborne illnesses. Much of the research has been focused on elucidating the mechanisms by which these pathogens evade the host immune system. One of the ways in which they achieve the successful establishment of a niche in the gut microenvironment and survive is by a chain of elegantly regulated gene expression patterns. Studies have shown that this process is very elaborate and is also regulated by several factors. Pathogens like, enteropathogenic Escherichia coli (EPEC), Salmonella Typhimurium, Shigella flexneri, Yersinia sp. have been seen to employ various regulated gene expression strategies. These include toxin-antitoxin systems, quorum sensing systems, expression controlled by nucleoid-associated proteins (NAPs), several regulons and operons specific to these pathogens. In the following review, we have tried to discuss the common gene regulatory systems of enteropathogenic bacteria as well as pathogen-specific regulatory mechanisms.
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spelling pubmed-63380472019-01-25 Enteropathogens: Tuning Their Gene Expression for Hassle-Free Survival Chatterjee, Ritika Shreenivas, Meghanashree M. Sunil, Rohith Chakravortty, Dipshikha Front Microbiol Microbiology Enteropathogenic bacteria have been the cause of the majority of foodborne illnesses. Much of the research has been focused on elucidating the mechanisms by which these pathogens evade the host immune system. One of the ways in which they achieve the successful establishment of a niche in the gut microenvironment and survive is by a chain of elegantly regulated gene expression patterns. Studies have shown that this process is very elaborate and is also regulated by several factors. Pathogens like, enteropathogenic Escherichia coli (EPEC), Salmonella Typhimurium, Shigella flexneri, Yersinia sp. have been seen to employ various regulated gene expression strategies. These include toxin-antitoxin systems, quorum sensing systems, expression controlled by nucleoid-associated proteins (NAPs), several regulons and operons specific to these pathogens. In the following review, we have tried to discuss the common gene regulatory systems of enteropathogenic bacteria as well as pathogen-specific regulatory mechanisms. Frontiers Media S.A. 2019-01-09 /pmc/articles/PMC6338047/ /pubmed/30687282 http://dx.doi.org/10.3389/fmicb.2018.03303 Text en Copyright © 2019 Chatterjee, Shreenivas, Sunil and Chakravortty. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Chatterjee, Ritika
Shreenivas, Meghanashree M.
Sunil, Rohith
Chakravortty, Dipshikha
Enteropathogens: Tuning Their Gene Expression for Hassle-Free Survival
title Enteropathogens: Tuning Their Gene Expression for Hassle-Free Survival
title_full Enteropathogens: Tuning Their Gene Expression for Hassle-Free Survival
title_fullStr Enteropathogens: Tuning Their Gene Expression for Hassle-Free Survival
title_full_unstemmed Enteropathogens: Tuning Their Gene Expression for Hassle-Free Survival
title_short Enteropathogens: Tuning Their Gene Expression for Hassle-Free Survival
title_sort enteropathogens: tuning their gene expression for hassle-free survival
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338047/
https://www.ncbi.nlm.nih.gov/pubmed/30687282
http://dx.doi.org/10.3389/fmicb.2018.03303
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