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Enteropathogens: Tuning Their Gene Expression for Hassle-Free Survival
Enteropathogenic bacteria have been the cause of the majority of foodborne illnesses. Much of the research has been focused on elucidating the mechanisms by which these pathogens evade the host immune system. One of the ways in which they achieve the successful establishment of a niche in the gut mi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338047/ https://www.ncbi.nlm.nih.gov/pubmed/30687282 http://dx.doi.org/10.3389/fmicb.2018.03303 |
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author | Chatterjee, Ritika Shreenivas, Meghanashree M. Sunil, Rohith Chakravortty, Dipshikha |
author_facet | Chatterjee, Ritika Shreenivas, Meghanashree M. Sunil, Rohith Chakravortty, Dipshikha |
author_sort | Chatterjee, Ritika |
collection | PubMed |
description | Enteropathogenic bacteria have been the cause of the majority of foodborne illnesses. Much of the research has been focused on elucidating the mechanisms by which these pathogens evade the host immune system. One of the ways in which they achieve the successful establishment of a niche in the gut microenvironment and survive is by a chain of elegantly regulated gene expression patterns. Studies have shown that this process is very elaborate and is also regulated by several factors. Pathogens like, enteropathogenic Escherichia coli (EPEC), Salmonella Typhimurium, Shigella flexneri, Yersinia sp. have been seen to employ various regulated gene expression strategies. These include toxin-antitoxin systems, quorum sensing systems, expression controlled by nucleoid-associated proteins (NAPs), several regulons and operons specific to these pathogens. In the following review, we have tried to discuss the common gene regulatory systems of enteropathogenic bacteria as well as pathogen-specific regulatory mechanisms. |
format | Online Article Text |
id | pubmed-6338047 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63380472019-01-25 Enteropathogens: Tuning Their Gene Expression for Hassle-Free Survival Chatterjee, Ritika Shreenivas, Meghanashree M. Sunil, Rohith Chakravortty, Dipshikha Front Microbiol Microbiology Enteropathogenic bacteria have been the cause of the majority of foodborne illnesses. Much of the research has been focused on elucidating the mechanisms by which these pathogens evade the host immune system. One of the ways in which they achieve the successful establishment of a niche in the gut microenvironment and survive is by a chain of elegantly regulated gene expression patterns. Studies have shown that this process is very elaborate and is also regulated by several factors. Pathogens like, enteropathogenic Escherichia coli (EPEC), Salmonella Typhimurium, Shigella flexneri, Yersinia sp. have been seen to employ various regulated gene expression strategies. These include toxin-antitoxin systems, quorum sensing systems, expression controlled by nucleoid-associated proteins (NAPs), several regulons and operons specific to these pathogens. In the following review, we have tried to discuss the common gene regulatory systems of enteropathogenic bacteria as well as pathogen-specific regulatory mechanisms. Frontiers Media S.A. 2019-01-09 /pmc/articles/PMC6338047/ /pubmed/30687282 http://dx.doi.org/10.3389/fmicb.2018.03303 Text en Copyright © 2019 Chatterjee, Shreenivas, Sunil and Chakravortty. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Chatterjee, Ritika Shreenivas, Meghanashree M. Sunil, Rohith Chakravortty, Dipshikha Enteropathogens: Tuning Their Gene Expression for Hassle-Free Survival |
title | Enteropathogens: Tuning Their Gene Expression for Hassle-Free Survival |
title_full | Enteropathogens: Tuning Their Gene Expression for Hassle-Free Survival |
title_fullStr | Enteropathogens: Tuning Their Gene Expression for Hassle-Free Survival |
title_full_unstemmed | Enteropathogens: Tuning Their Gene Expression for Hassle-Free Survival |
title_short | Enteropathogens: Tuning Their Gene Expression for Hassle-Free Survival |
title_sort | enteropathogens: tuning their gene expression for hassle-free survival |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338047/ https://www.ncbi.nlm.nih.gov/pubmed/30687282 http://dx.doi.org/10.3389/fmicb.2018.03303 |
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