The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome

OBJECTIVE: The role of the hydroxycarboxylic acid receptor 2 (HCA(2)) in the retinal damage induced by diabetes has never been explored. In this context, the present study highlights an upregulation of retinal HCA(2) receptors in diabetic C57BL6J mice. Moreover, we illustrate that HCA(2) receptors e...

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Detalles Bibliográficos
Autores principales: Trotta, Maria Consiglia, Maisto, Rosa, Guida, Francesca, Boccella, Serena, Luongo, Livio, Balta, Cornel, D’Amico, Giovanbattista, Herman, Hildegard, Hermenean, Anca, Bucolo, Claudio, D’Amico, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338370/
https://www.ncbi.nlm.nih.gov/pubmed/30657794
http://dx.doi.org/10.1371/journal.pone.0211005

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