Myeloid-specific targeting of Notch ameliorates murine renal fibrosis via reduced infiltration and activation of bone marrow-derived macrophage

Macrophages play critical roles in renal fibrosis. However, macrophages exhibit ontogenic and functional heterogeneities, and which population of macrophages contributes to renal fibrosis and the underlying mechanisms remain unclear. In this study, we genetically targeted Notch signaling by disrupti...

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Detalles Bibliográficos
Autores principales: Jiang, Yali, Wang, Yuanyuan, Ma, Pengfei, An, Dongjie, Zhao, Junlong, Liang, Shiqian, Ye, Yuchen, Lu, Yingying, Zhang, Peng, Liu, Xiaowei, Han, Hua, Qin, Hongyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338623/
https://www.ncbi.nlm.nih.gov/pubmed/29644573
http://dx.doi.org/10.1007/s13238-018-0527-6

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