Phosphorylation of MCPH1 isoforms during mitosis followed by isoform-specific degradation by APC/C-CDH1

Microcephalin-1 (MCPH1) exists as 2 isoforms that regulate cyclin-dependent kinase-1 activation and chromosome condensation during mitosis, with MCPH1 mutations causing primary microcephaly. MCPH1 is also a tumor suppressor protein, with roles in DNA damage repair/checkpoints. Despite these importan...

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Detalles Bibliográficos
Autores principales: Meyer, Stephanie K., Dunn, Michael, Vidler, Daniel S., Porter, Andrew, Blain, Peter G., Jowsey, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338662/
https://www.ncbi.nlm.nih.gov/pubmed/30303738
http://dx.doi.org/10.1096/fj.201801353R

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