Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis

Despite the wealth of genomic and transcriptomic data in Parkinson’s disease (PD), the initial molecular events are unknown. Using LD score regression analysis, we show significant enrichment in PD heritability within regulatory sites for LPS-activated monocytes and that TLR4 expression is highest w...

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Detalles Bibliográficos
Autores principales: Hughes, Craig D., Choi, Minee L., Ryten, Mina, Hopkins, Lee, Drews, Anna, Botía, Juan A., Iljina, Maria, Rodrigues, Margarida, Gagliano, Sarah A., Gandhi, Sonia, Bryant, Clare, Klenerman, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338693/
https://www.ncbi.nlm.nih.gov/pubmed/30225556
http://dx.doi.org/10.1007/s00401-018-1907-y

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