Blocking CXCLs–CXCR2 axis in tumor–stromal interactions contributes to survival in a mouse model of pancreatic ductal adenocarcinoma through reduced cell invasion/migration and a shift of immune-inflammatory microenvironment

Pancreatic ductal adenocarcinoma (PDAC) is characterized by dense stromal reaction (desmoplasia). We have previously reported that mice with conditional Kras(G12D) mutation and knockout of TGF-β receptor type II (Tgfbr2), PKF mice, develop PDAC with desmoplasia modulated by CXC chemokines that are p...

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Detalles Bibliográficos
Autores principales: Sano, Makoto, Ijichi, Hideaki, Takahashi, Ryota, Miyabayashi, Koji, Fujiwara, Hiroaki, Yamada, Tomoharu, Kato, Hiroyuki, Nakatsuka, Takuma, Tanaka, Yasuo, Tateishi, Keisuke, Morishita, Yasuyuki, Moses, Harold L., Isayama, Hiroyuki, Koike, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338726/
https://www.ncbi.nlm.nih.gov/pubmed/30659170
http://dx.doi.org/10.1038/s41389-018-0117-8

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