Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs

The platinum-based drug cisplatin is a widely used first-line therapy for several cancers. Cisplatin interacts with DNA mainly in the form of Pt-d(GpG) di-adduct, which stalls cell proliferation and activates DNA damage response. Although cisplatin shows a broad spectrum of anticancer activity, its...

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Detalles Bibliográficos
Autores principales: Yimit, Askar, Adebali, Ogun, Sancar, Aziz, Jiang, Yuchao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338751/
https://www.ncbi.nlm.nih.gov/pubmed/30659176
http://dx.doi.org/10.1038/s41467-019-08290-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338751/
https://www.ncbi.nlm.nih.gov/pubmed/30659176
http://dx.doi.org/10.1038/s41467-019-08290-2

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