Cargando…

A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats

We previously demonstrated that beta II protein kinase C (βIIPKC) activity is elevated in failing hearts and contributes to this pathology. Here we report that βIIPKC accumulates on the mitochondrial outer membrane and phosphorylates mitofusin 1 (Mfn1) at serine 86. Mfn1 phosphorylation results in p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ferreira, Julio C. B., Campos, Juliane C., Qvit, Nir, Qi, Xin, Bozi, Luiz H. M., Bechara, Luiz R. G., Lima, Vanessa M., Queliconi, Bruno B., Disatnik, Marie-Helene, Dourado, Paulo M. M., Kowaltowski, Alicia J., Mochly-Rosen, Daria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338754/ https://www.ncbi.nlm.nih.gov/pubmed/30659190 http://dx.doi.org/10.1038/s41467-018-08276-6

Ejemplares similares

Exercise Training Restores Cardiac Protein Quality Control in Heart Failure
por: Campos, Juliane C., et al.
Publicado: (2012)

Acute Inhibition of Excessive Mitochondrial Fission After Myocardial Infarction Prevents Long‐term Cardiac Dysfunction
por: Disatnik, Marie‐Hélène, et al.
Publicado: (2013)

A Selective Inhibitor of Cardiac Troponin I Phosphorylation by Delta Protein Kinase C (δPKC) as a Treatment for Ischemia-Reperfusion Injury
por: Qvit, Nir, et al.
Publicado: (2022)

New therapeutics to modulate mitochondrial dynamics and mitophagy in cardiac diseases
por: Disatnik, Marie-Hélène, et al.
Publicado: (2015)

Mitochondrial Quality Control in Cardiac Diseases
por: Campos, Juliane C., et al.
Publicado: (2016)

Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington’s disease
por: Hwang, Sunhee, et al.
Publicado: (2015)

The challenge in translating basic research discoveries to treatment of Huntington disease
por: Mochly-Rosen, Daria, et al.
Publicado: (2014)

Interaction of mitochondrial fission factor with dynamin related protein 1 governs physiological mitochondrial function in vivo
por: Kornfeld, Opher S., et al.
Publicado: (2018)

An Anoxia-starvation Model for Ischemia/Reperfusion in C. elegans
por: Queliconi, Bruno B., et al.
Publicado: (2014)

Aberrant mitochondrial fission in neurons induced by protein kinase Cδ under oxidative stress conditions in vivo
por: Qi, Xin, et al.
Publicado: (2011)

Aldehyde dehydrogenase 2 activation and coevolution of its εPKC-mediated phosphorylation sites
por: Nene, Aishwarya, et al.
Publicado: (2017)

Mitochondrial import of PKCε is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury
por: Budas, Grant R., et al.
Publicado: (2010)

Bicarbonate Increases Ischemia-Reperfusion Damage by Inhibiting Mitophagy
por: Queliconi, Bruno B., et al.
Publicado: (2016)

Potential biomarkers to follow the progression and treatment response of Huntington’s disease
por: Disatnik, Marie-Hélène, et al.
Publicado: (2016)

Exercise prevents impaired autophagy and proteostasis in a model of neurogenic myopathy
por: Campos, Juliane C., et al.
Publicado: (2018)

Transient Receptor Potential Vanilloid 1 Regulates Mitochondrial Membrane Potential and Myocardial Reperfusion Injury
por: Hurt, Carl M., et al.
Publicado: (2016)

Autophagy Signaling in Skeletal Muscle of Infarcted Rats
por: Jannig, Paulo R., et al.
Publicado: (2014)

A new target for an old DUB: UCH-L1 regulates mitofusin-2 levels, altering mitochondrial morphology, function and calcium uptake
por: Cerqueira, Fernanda M., et al.
Publicado: (2020)

Role of Mitofusin 2 in the Renal Stress Response
por: Gall, Jonathan M., et al.
Publicado: (2012)

Aerobic exercise training rescues cardiac protein quality control and blunts endoplasmic reticulum stress in heart failure rats
por: Bozi, Luiz H. M., et al.
Publicado: (2016)

Pro-diversity mitofusins
por: LeBrasseur, Nicole
Publicado: (2007)

The INs and OUTs of mitofusins
por: Giacomello, Marta, et al.
Publicado: (2018)

Mitofusins: from mitochondria to fertility
por: Zhao, Shanjiang, et al.
Publicado: (2022)

Protein Quality Control Disruption by PKCβII in Heart Failure; Rescue by the Selective PKCβII Inhibitor, βIIV5-3
por: Ferreira, Julio C. B., et al.
Publicado: (2012)

Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins
por: Yu, Chia-Yi, et al.
Publicado: (2015)

Recent insights into the structure and function of Mitofusins in mitochondrial fusion
por: Cohen, Mickael M, et al.
Publicado: (2018)

Mitofusin 2: from functions to disease
por: Filadi, Riccardo, et al.
Publicado: (2018)

Exercise preserves physical fitness during aging through AMPK and mitochondrial dynamics
por: Campos, Juliane Cruz, et al.
Publicado: (2023)

Focus On: The Cardiovascular System: What Did We Learn from the French (Paradox)?
por: Mochly-Rosen, Daria, et al.
Publicado: (2010)

Discovery and Preclinical Work
por: Mochly-Rosen, Daria, et al.
Publicado: (2013)

Structural analysis of clinically relevant pathogenic G6PD variants reveals the importance of tetramerization for G6PD activity
por: Cunningham, Anna D, et al.
Publicado: (2017)

How Similar Are Proteins and Origami?
por: Azulay, Hay, et al.
Publicado: (2022)

The Drp1-Mediated Mitochondrial Fission Protein Interactome as an Emerging Core Player in Mitochondrial Dynamics and Cardiovascular Disease Therapy
por: Zerihun, Mulate, et al.
Publicado: (2023)

Ischaemic preconditioning improves proteasomal activity and increases the degradation of δPKC during reperfusion
por: Churchill, Eric N., et al.
Publicado: (2010)

Downregulation of Mitofusin 2 in Placenta Is Related to Preeclampsia
por: Yu, Jun, et al.
Publicado: (2016)

Mitofusin 2 keeps the respiratory chain on Q
por: Short, Ben
Publicado: (2015)

Mitochondrial fusion: Reaching the end of mitofusin’s tether
por: Formosa, Luke E., et al.
Publicado: (2016)

Mitofusin1 in oocyte is essential for female fertility
por: Hou, Xiaojing, et al.
Publicado: (2019)

Role of Mitofusins and Mitophagy in Life or Death Decisions
por: Joaquim, Mariana, et al.
Publicado: (2020)

Mitofusin 2 Dysfunction and Disease in Mice and Men
por: Dorn, Gerald W.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_82d7uuehoqphv2ft1at5f4mb2j