Epstein-Barr Virus Latent Membrane Protein-1 Induces the Expression of SUMO-1 and SUMO-2/3 in LMP1-positive Lymphomas and Cells

Epstein-Barr Virus latent membrane protein-1 (LMP1) interacts with the SUMO-conjugating enzyme Ubc9, which induces protein sumoylation and may contribute to LMP1-mediated oncogenesis. After analyzing human lymphoma tissues and EBV-positive cell lines, we now document a strong correlation between LMP...

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Detalles Bibliográficos
Autores principales: Salahuddin, Sadia, Fath, Emma K., Biel, Natalie, Ray, Ashley, Moss, C. Randall, Patel, Akash, Patel, Sheetal, Hilding, Leslie, Varn, Matthew, Ross, Tabithia, Cramblet, Wyatt T., Lowrey, Angela, Pagano, Joseph S., Shackelford, Julia, Bentz, Gretchen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338769/
https://www.ncbi.nlm.nih.gov/pubmed/30659232
http://dx.doi.org/10.1038/s41598-018-36312-4
Descripción
Sumario:Epstein-Barr Virus latent membrane protein-1 (LMP1) interacts with the SUMO-conjugating enzyme Ubc9, which induces protein sumoylation and may contribute to LMP1-mediated oncogenesis. After analyzing human lymphoma tissues and EBV-positive cell lines, we now document a strong correlation between LMP1 and sumo-1/2/3 or SUMO-1/2/3 levels, and show that LMP1-induced sumo expression requires the activation of NF-κB signaling through CTAR1 and CTAR2. Together, these results point to a second mechanism by which LMP1 dysregulates sumoylation processes and adds EBV-associated lymphomas to the list of malignancies associated with increased SUMO expression.

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