Epstein-Barr Virus Latent Membrane Protein-1 Induces the Expression of SUMO-1 and SUMO-2/3 in LMP1-positive Lymphomas and Cells

Epstein-Barr Virus latent membrane protein-1 (LMP1) interacts with the SUMO-conjugating enzyme Ubc9, which induces protein sumoylation and may contribute to LMP1-mediated oncogenesis. After analyzing human lymphoma tissues and EBV-positive cell lines, we now document a strong correlation between LMP...

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Autores principales: Salahuddin, Sadia, Fath, Emma K., Biel, Natalie, Ray, Ashley, Moss, C. Randall, Patel, Akash, Patel, Sheetal, Hilding, Leslie, Varn, Matthew, Ross, Tabithia, Cramblet, Wyatt T., Lowrey, Angela, Pagano, Joseph S., Shackelford, Julia, Bentz, Gretchen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338769/
https://www.ncbi.nlm.nih.gov/pubmed/30659232
http://dx.doi.org/10.1038/s41598-018-36312-4
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author Salahuddin, Sadia
Fath, Emma K.
Biel, Natalie
Ray, Ashley
Moss, C. Randall
Patel, Akash
Patel, Sheetal
Hilding, Leslie
Varn, Matthew
Ross, Tabithia
Cramblet, Wyatt T.
Lowrey, Angela
Pagano, Joseph S.
Shackelford, Julia
Bentz, Gretchen L.
author_facet Salahuddin, Sadia
Fath, Emma K.
Biel, Natalie
Ray, Ashley
Moss, C. Randall
Patel, Akash
Patel, Sheetal
Hilding, Leslie
Varn, Matthew
Ross, Tabithia
Cramblet, Wyatt T.
Lowrey, Angela
Pagano, Joseph S.
Shackelford, Julia
Bentz, Gretchen L.
author_sort Salahuddin, Sadia
collection PubMed
description Epstein-Barr Virus latent membrane protein-1 (LMP1) interacts with the SUMO-conjugating enzyme Ubc9, which induces protein sumoylation and may contribute to LMP1-mediated oncogenesis. After analyzing human lymphoma tissues and EBV-positive cell lines, we now document a strong correlation between LMP1 and sumo-1/2/3 or SUMO-1/2/3 levels, and show that LMP1-induced sumo expression requires the activation of NF-κB signaling through CTAR1 and CTAR2. Together, these results point to a second mechanism by which LMP1 dysregulates sumoylation processes and adds EBV-associated lymphomas to the list of malignancies associated with increased SUMO expression.
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spelling pubmed-63387692019-01-23 Epstein-Barr Virus Latent Membrane Protein-1 Induces the Expression of SUMO-1 and SUMO-2/3 in LMP1-positive Lymphomas and Cells Salahuddin, Sadia Fath, Emma K. Biel, Natalie Ray, Ashley Moss, C. Randall Patel, Akash Patel, Sheetal Hilding, Leslie Varn, Matthew Ross, Tabithia Cramblet, Wyatt T. Lowrey, Angela Pagano, Joseph S. Shackelford, Julia Bentz, Gretchen L. Sci Rep Article Epstein-Barr Virus latent membrane protein-1 (LMP1) interacts with the SUMO-conjugating enzyme Ubc9, which induces protein sumoylation and may contribute to LMP1-mediated oncogenesis. After analyzing human lymphoma tissues and EBV-positive cell lines, we now document a strong correlation between LMP1 and sumo-1/2/3 or SUMO-1/2/3 levels, and show that LMP1-induced sumo expression requires the activation of NF-κB signaling through CTAR1 and CTAR2. Together, these results point to a second mechanism by which LMP1 dysregulates sumoylation processes and adds EBV-associated lymphomas to the list of malignancies associated with increased SUMO expression. Nature Publishing Group UK 2019-01-18 /pmc/articles/PMC6338769/ /pubmed/30659232 http://dx.doi.org/10.1038/s41598-018-36312-4 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Salahuddin, Sadia
Fath, Emma K.
Biel, Natalie
Ray, Ashley
Moss, C. Randall
Patel, Akash
Patel, Sheetal
Hilding, Leslie
Varn, Matthew
Ross, Tabithia
Cramblet, Wyatt T.
Lowrey, Angela
Pagano, Joseph S.
Shackelford, Julia
Bentz, Gretchen L.
Epstein-Barr Virus Latent Membrane Protein-1 Induces the Expression of SUMO-1 and SUMO-2/3 in LMP1-positive Lymphomas and Cells
title Epstein-Barr Virus Latent Membrane Protein-1 Induces the Expression of SUMO-1 and SUMO-2/3 in LMP1-positive Lymphomas and Cells
title_full Epstein-Barr Virus Latent Membrane Protein-1 Induces the Expression of SUMO-1 and SUMO-2/3 in LMP1-positive Lymphomas and Cells
title_fullStr Epstein-Barr Virus Latent Membrane Protein-1 Induces the Expression of SUMO-1 and SUMO-2/3 in LMP1-positive Lymphomas and Cells
title_full_unstemmed Epstein-Barr Virus Latent Membrane Protein-1 Induces the Expression of SUMO-1 and SUMO-2/3 in LMP1-positive Lymphomas and Cells
title_short Epstein-Barr Virus Latent Membrane Protein-1 Induces the Expression of SUMO-1 and SUMO-2/3 in LMP1-positive Lymphomas and Cells
title_sort epstein-barr virus latent membrane protein-1 induces the expression of sumo-1 and sumo-2/3 in lmp1-positive lymphomas and cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338769/
https://www.ncbi.nlm.nih.gov/pubmed/30659232
http://dx.doi.org/10.1038/s41598-018-36312-4
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