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Single-molecule imaging of the transcription factor SRF reveals prolonged chromatin-binding kinetics upon cell stimulation

Serum response factor (SRF) mediates immediate early gene (IEG) and cytoskeletal gene expression programs in almost any cell type. So far, SRF transcriptional dynamics have not been investigated at single-molecule resolution. We provide a study of single Halo-tagged SRF molecules in fibroblasts and...

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Detalles Bibliográficos
Autores principales:	Hipp, Lisa, Beer, Judith, Kuchler, Oliver, Reisser, Matthias, Sinske, Daniela, Michaelis, Jens, Gebhardt, J. Christof M., Knöll, Bernd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2019
Materias:	PNAS Plus
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338867/ https://www.ncbi.nlm.nih.gov/pubmed/30598445 http://dx.doi.org/10.1073/pnas.1812734116

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