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Diagnosis of HELLP Syndrome: A 10-Year Survey in a Perinatology Centre

HELLP (Hemolysis, Elevated Liver enzymes, Low Platelet count) syndrome is a severe and rapidly progressing condition that requires distinct diagnostic considerations. The aim of this study was to evaluate the impact of the Mississippi triple-class system on the HELLP syndrome diagnosis, treatment, a...

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Autores principales: Rimaitis, Kestutis, Grauslyte, Lina, Zavackiene, Asta, Baliuliene, Vilda, Nadisauskiene, Ruta, Macas, Andrius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339138/
https://www.ncbi.nlm.nih.gov/pubmed/30609811
http://dx.doi.org/10.3390/ijerph16010109
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author Rimaitis, Kestutis
Grauslyte, Lina
Zavackiene, Asta
Baliuliene, Vilda
Nadisauskiene, Ruta
Macas, Andrius
author_facet Rimaitis, Kestutis
Grauslyte, Lina
Zavackiene, Asta
Baliuliene, Vilda
Nadisauskiene, Ruta
Macas, Andrius
author_sort Rimaitis, Kestutis
collection PubMed
description HELLP (Hemolysis, Elevated Liver enzymes, Low Platelet count) syndrome is a severe and rapidly progressing condition that requires distinct diagnostic considerations. The aim of this study was to evaluate the impact of the Mississippi triple-class system on the HELLP syndrome diagnosis, treatment, and outcomes in a perinatology centre during a 10-year period, and consider its effectiveness and necessity in everyday practice. A retrospective observational cohort study was carried out using the medical records of a tertiary perinatology centre with the diagnosis of HELLP syndrome from the period of time between 2005 and 2014. The patients who fit the HELLP syndrome diagnosis were grouped by the Mississippi triple-class system. The means of diagnosis and treatment outcomes within those groups were analysed statistically. There was insufficient statistical evidence of the blood pressure levels corresponding to the severity of patients’ condition (p > 0.05 in all of the groups). The clinical presentation varied within all of the classes, and the only objective means of diagnosis and evaluation of progression of the condition were laboratory tests. Even though HELLP syndrome is considered a hypertensive multi-organ disorder of pregnancy, the level of hypertension does not correlate to the severity of the condition; hence, the diagnosis should be based on biochemical laboratory evidence. Vigilance in suspicion and the recognition of HELLP syndrome and appropriate treatment are essential in order to ensure better maternal and neonatal outcomes.
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spelling pubmed-63391382019-01-23 Diagnosis of HELLP Syndrome: A 10-Year Survey in a Perinatology Centre Rimaitis, Kestutis Grauslyte, Lina Zavackiene, Asta Baliuliene, Vilda Nadisauskiene, Ruta Macas, Andrius Int J Environ Res Public Health Article HELLP (Hemolysis, Elevated Liver enzymes, Low Platelet count) syndrome is a severe and rapidly progressing condition that requires distinct diagnostic considerations. The aim of this study was to evaluate the impact of the Mississippi triple-class system on the HELLP syndrome diagnosis, treatment, and outcomes in a perinatology centre during a 10-year period, and consider its effectiveness and necessity in everyday practice. A retrospective observational cohort study was carried out using the medical records of a tertiary perinatology centre with the diagnosis of HELLP syndrome from the period of time between 2005 and 2014. The patients who fit the HELLP syndrome diagnosis were grouped by the Mississippi triple-class system. The means of diagnosis and treatment outcomes within those groups were analysed statistically. There was insufficient statistical evidence of the blood pressure levels corresponding to the severity of patients’ condition (p > 0.05 in all of the groups). The clinical presentation varied within all of the classes, and the only objective means of diagnosis and evaluation of progression of the condition were laboratory tests. Even though HELLP syndrome is considered a hypertensive multi-organ disorder of pregnancy, the level of hypertension does not correlate to the severity of the condition; hence, the diagnosis should be based on biochemical laboratory evidence. Vigilance in suspicion and the recognition of HELLP syndrome and appropriate treatment are essential in order to ensure better maternal and neonatal outcomes. MDPI 2019-01-03 2019-01 /pmc/articles/PMC6339138/ /pubmed/30609811 http://dx.doi.org/10.3390/ijerph16010109 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rimaitis, Kestutis
Grauslyte, Lina
Zavackiene, Asta
Baliuliene, Vilda
Nadisauskiene, Ruta
Macas, Andrius
Diagnosis of HELLP Syndrome: A 10-Year Survey in a Perinatology Centre
title Diagnosis of HELLP Syndrome: A 10-Year Survey in a Perinatology Centre
title_full Diagnosis of HELLP Syndrome: A 10-Year Survey in a Perinatology Centre
title_fullStr Diagnosis of HELLP Syndrome: A 10-Year Survey in a Perinatology Centre
title_full_unstemmed Diagnosis of HELLP Syndrome: A 10-Year Survey in a Perinatology Centre
title_short Diagnosis of HELLP Syndrome: A 10-Year Survey in a Perinatology Centre
title_sort diagnosis of hellp syndrome: a 10-year survey in a perinatology centre
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339138/
https://www.ncbi.nlm.nih.gov/pubmed/30609811
http://dx.doi.org/10.3390/ijerph16010109
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