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A Case of Listeria monocytogenes ST-219 Meningo-Encephalitis
Listeriosis is a foodborne disease characterized by high hospitalization and fatality rates, especially in vulnerable groups including elderly subjects, pregnant women, etc. We report on the first case of Listeria monocytogenes ST-219 meningo-encephalitis in a woman aged 83 years. An epidemiological...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339192/ https://www.ncbi.nlm.nih.gov/pubmed/30577534 http://dx.doi.org/10.3390/ijerph16010008 |
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author | Sotgiu, Giovanni Muresu, Narcisa Dettori, Marco Mura, Erica Cossu, Andrea Masia, Maria Dolores Murgia, Paola Cocuzza, Clementina De Santis, Enrico Pietro Luigi Scarano, Christian Spanu, Carlo Piana, Andrea |
author_facet | Sotgiu, Giovanni Muresu, Narcisa Dettori, Marco Mura, Erica Cossu, Andrea Masia, Maria Dolores Murgia, Paola Cocuzza, Clementina De Santis, Enrico Pietro Luigi Scarano, Christian Spanu, Carlo Piana, Andrea |
author_sort | Sotgiu, Giovanni |
collection | PubMed |
description | Listeriosis is a foodborne disease characterized by high hospitalization and fatality rates, especially in vulnerable groups including elderly subjects, pregnant women, etc. We report on the first case of Listeria monocytogenes ST-219 meningo-encephalitis in a woman aged 83 years. An epidemiological and molecular investigation was performed to detect the source of infection and the virulence factors associated with L. monocytogenes invasiveness in this patient. All environmental- and clinical-associated isolates were found to belong to serotype 4b and ST-219 as well as possessing actA, prfA, hlyA, and rrn virulence genes. Antibiotic susceptibility testing also detected resistance to cotrimoxazole, clindamycin, erythromycin, and oxacillin in these isolates. Conventional and molecular surveillance of listeriosis cases, based on the systematic assessment of spatio-temporal trends, virulence genes, and antimicrobial susceptibility testing patterns, are key to preventing and controlling the emergence and spread of L. monocytogenes strains, including hypervirulent clones. |
format | Online Article Text |
id | pubmed-6339192 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63391922019-01-23 A Case of Listeria monocytogenes ST-219 Meningo-Encephalitis Sotgiu, Giovanni Muresu, Narcisa Dettori, Marco Mura, Erica Cossu, Andrea Masia, Maria Dolores Murgia, Paola Cocuzza, Clementina De Santis, Enrico Pietro Luigi Scarano, Christian Spanu, Carlo Piana, Andrea Int J Environ Res Public Health Case Report Listeriosis is a foodborne disease characterized by high hospitalization and fatality rates, especially in vulnerable groups including elderly subjects, pregnant women, etc. We report on the first case of Listeria monocytogenes ST-219 meningo-encephalitis in a woman aged 83 years. An epidemiological and molecular investigation was performed to detect the source of infection and the virulence factors associated with L. monocytogenes invasiveness in this patient. All environmental- and clinical-associated isolates were found to belong to serotype 4b and ST-219 as well as possessing actA, prfA, hlyA, and rrn virulence genes. Antibiotic susceptibility testing also detected resistance to cotrimoxazole, clindamycin, erythromycin, and oxacillin in these isolates. Conventional and molecular surveillance of listeriosis cases, based on the systematic assessment of spatio-temporal trends, virulence genes, and antimicrobial susceptibility testing patterns, are key to preventing and controlling the emergence and spread of L. monocytogenes strains, including hypervirulent clones. MDPI 2018-12-20 2019-01 /pmc/articles/PMC6339192/ /pubmed/30577534 http://dx.doi.org/10.3390/ijerph16010008 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Sotgiu, Giovanni Muresu, Narcisa Dettori, Marco Mura, Erica Cossu, Andrea Masia, Maria Dolores Murgia, Paola Cocuzza, Clementina De Santis, Enrico Pietro Luigi Scarano, Christian Spanu, Carlo Piana, Andrea A Case of Listeria monocytogenes ST-219 Meningo-Encephalitis |
title | A Case of Listeria monocytogenes ST-219 Meningo-Encephalitis |
title_full | A Case of Listeria monocytogenes ST-219 Meningo-Encephalitis |
title_fullStr | A Case of Listeria monocytogenes ST-219 Meningo-Encephalitis |
title_full_unstemmed | A Case of Listeria monocytogenes ST-219 Meningo-Encephalitis |
title_short | A Case of Listeria monocytogenes ST-219 Meningo-Encephalitis |
title_sort | case of listeria monocytogenes st-219 meningo-encephalitis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339192/ https://www.ncbi.nlm.nih.gov/pubmed/30577534 http://dx.doi.org/10.3390/ijerph16010008 |
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