Cargando…

Prognostic Value of the Modified Atherogenic Index of Plasma during Body Mass Reduction in Polish Obese/Overweight People

Although weight loss is recommended for obese patients, it remains questionable how much weight loss is optimal. A novel index that accurately determines the risk of cardiovascular diseases (CVDs) in terms of weight loss is needed. The modified Atherogenic Index of Plasma (AIP), presented here is un...

Descripción completa

Detalles Bibliográficos
Autores principales: Zalejska-Fiolka, Jolanta, Hubková, Beáta, Birková, Anna, Veliká, Beáta, Puchalska, Beata, Kasperczyk, Sławomir, Błaszczyk, Urszula, Fiolka, Rafał, Bożek, Andrzej, Maksym, Beata, Mareková, Mária, Birkner, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339198/
https://www.ncbi.nlm.nih.gov/pubmed/30591697
http://dx.doi.org/10.3390/ijerph16010068
_version_ 1783388583360462848
author Zalejska-Fiolka, Jolanta
Hubková, Beáta
Birková, Anna
Veliká, Beáta
Puchalska, Beata
Kasperczyk, Sławomir
Błaszczyk, Urszula
Fiolka, Rafał
Bożek, Andrzej
Maksym, Beata
Mareková, Mária
Birkner, Ewa
author_facet Zalejska-Fiolka, Jolanta
Hubková, Beáta
Birková, Anna
Veliká, Beáta
Puchalska, Beata
Kasperczyk, Sławomir
Błaszczyk, Urszula
Fiolka, Rafał
Bożek, Andrzej
Maksym, Beata
Mareková, Mária
Birkner, Ewa
author_sort Zalejska-Fiolka, Jolanta
collection PubMed
description Although weight loss is recommended for obese patients, it remains questionable how much weight loss is optimal. A novel index that accurately determines the risk of cardiovascular diseases (CVDs) in terms of weight loss is needed. The modified Atherogenic Index of Plasma (AIP), presented here is unique in the literature. It is calculated based on data for anti-atherogenic, high-density lipoprotein cholesterol (HDL-C) fractions, instead of the total HDL-C. This study investigates whether weight loss correlates with CVD risk, and whether the modified AIP allows more accurate diagnostics in obese/overweight people. According to the increase or decrease of AIP during weight loss, 52 Polish patients were subdivided into two groups: group I (increased AIP; n = 16) and group II (decreased AIP; n = 36). The patients’ body mass composition and fasting serum lipid parameters (total cholesterol, triglycerides, HDL-C, and LDL-C (low-density lipoprotein cholesterol)), and cholesterol in 21 lipoprotein sub-fractions were determined. Over six months, all patients reduced their body mass by about 10%. There were no significant differences in anthropometric measures between groups. Increases in large and intermediate HDL-C fractions 1 to 6 and decreases in smaller fractions 7 to 10 were observed in group II. In group I, HDL-C fractions 1 and 10 decreased, while cholesterol in other fractions increased. Increases were observed in the antiatherogenic HDL-C of 52% of group II and 4% of group I. As for atherogenic HDL-C, a decrease of 24% was observed in group II and an increase of 9% in group I. In group I, increases of very-low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), and large LDL fractions were noticed, and the reverse in group II. The results show that the modified AIP is a more accurate indicator of CVD risk than existing indices, and that uncontrolled weight reduction does not necessarily have a beneficial influence, and may adversely affect the cardiovascular system.
format Online
Article
Text
id pubmed-6339198
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-63391982019-01-23 Prognostic Value of the Modified Atherogenic Index of Plasma during Body Mass Reduction in Polish Obese/Overweight People Zalejska-Fiolka, Jolanta Hubková, Beáta Birková, Anna Veliká, Beáta Puchalska, Beata Kasperczyk, Sławomir Błaszczyk, Urszula Fiolka, Rafał Bożek, Andrzej Maksym, Beata Mareková, Mária Birkner, Ewa Int J Environ Res Public Health Article Although weight loss is recommended for obese patients, it remains questionable how much weight loss is optimal. A novel index that accurately determines the risk of cardiovascular diseases (CVDs) in terms of weight loss is needed. The modified Atherogenic Index of Plasma (AIP), presented here is unique in the literature. It is calculated based on data for anti-atherogenic, high-density lipoprotein cholesterol (HDL-C) fractions, instead of the total HDL-C. This study investigates whether weight loss correlates with CVD risk, and whether the modified AIP allows more accurate diagnostics in obese/overweight people. According to the increase or decrease of AIP during weight loss, 52 Polish patients were subdivided into two groups: group I (increased AIP; n = 16) and group II (decreased AIP; n = 36). The patients’ body mass composition and fasting serum lipid parameters (total cholesterol, triglycerides, HDL-C, and LDL-C (low-density lipoprotein cholesterol)), and cholesterol in 21 lipoprotein sub-fractions were determined. Over six months, all patients reduced their body mass by about 10%. There were no significant differences in anthropometric measures between groups. Increases in large and intermediate HDL-C fractions 1 to 6 and decreases in smaller fractions 7 to 10 were observed in group II. In group I, HDL-C fractions 1 and 10 decreased, while cholesterol in other fractions increased. Increases were observed in the antiatherogenic HDL-C of 52% of group II and 4% of group I. As for atherogenic HDL-C, a decrease of 24% was observed in group II and an increase of 9% in group I. In group I, increases of very-low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), and large LDL fractions were noticed, and the reverse in group II. The results show that the modified AIP is a more accurate indicator of CVD risk than existing indices, and that uncontrolled weight reduction does not necessarily have a beneficial influence, and may adversely affect the cardiovascular system. MDPI 2018-12-27 2019-01 /pmc/articles/PMC6339198/ /pubmed/30591697 http://dx.doi.org/10.3390/ijerph16010068 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zalejska-Fiolka, Jolanta
Hubková, Beáta
Birková, Anna
Veliká, Beáta
Puchalska, Beata
Kasperczyk, Sławomir
Błaszczyk, Urszula
Fiolka, Rafał
Bożek, Andrzej
Maksym, Beata
Mareková, Mária
Birkner, Ewa
Prognostic Value of the Modified Atherogenic Index of Plasma during Body Mass Reduction in Polish Obese/Overweight People
title Prognostic Value of the Modified Atherogenic Index of Plasma during Body Mass Reduction in Polish Obese/Overweight People
title_full Prognostic Value of the Modified Atherogenic Index of Plasma during Body Mass Reduction in Polish Obese/Overweight People
title_fullStr Prognostic Value of the Modified Atherogenic Index of Plasma during Body Mass Reduction in Polish Obese/Overweight People
title_full_unstemmed Prognostic Value of the Modified Atherogenic Index of Plasma during Body Mass Reduction in Polish Obese/Overweight People
title_short Prognostic Value of the Modified Atherogenic Index of Plasma during Body Mass Reduction in Polish Obese/Overweight People
title_sort prognostic value of the modified atherogenic index of plasma during body mass reduction in polish obese/overweight people
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339198/
https://www.ncbi.nlm.nih.gov/pubmed/30591697
http://dx.doi.org/10.3390/ijerph16010068
work_keys_str_mv AT zalejskafiolkajolanta prognosticvalueofthemodifiedatherogenicindexofplasmaduringbodymassreductioninpolishobeseoverweightpeople
AT hubkovabeata prognosticvalueofthemodifiedatherogenicindexofplasmaduringbodymassreductioninpolishobeseoverweightpeople
AT birkovaanna prognosticvalueofthemodifiedatherogenicindexofplasmaduringbodymassreductioninpolishobeseoverweightpeople
AT velikabeata prognosticvalueofthemodifiedatherogenicindexofplasmaduringbodymassreductioninpolishobeseoverweightpeople
AT puchalskabeata prognosticvalueofthemodifiedatherogenicindexofplasmaduringbodymassreductioninpolishobeseoverweightpeople
AT kasperczyksławomir prognosticvalueofthemodifiedatherogenicindexofplasmaduringbodymassreductioninpolishobeseoverweightpeople
AT błaszczykurszula prognosticvalueofthemodifiedatherogenicindexofplasmaduringbodymassreductioninpolishobeseoverweightpeople
AT fiolkarafał prognosticvalueofthemodifiedatherogenicindexofplasmaduringbodymassreductioninpolishobeseoverweightpeople
AT bozekandrzej prognosticvalueofthemodifiedatherogenicindexofplasmaduringbodymassreductioninpolishobeseoverweightpeople
AT maksymbeata prognosticvalueofthemodifiedatherogenicindexofplasmaduringbodymassreductioninpolishobeseoverweightpeople
AT marekovamaria prognosticvalueofthemodifiedatherogenicindexofplasmaduringbodymassreductioninpolishobeseoverweightpeople
AT birknerewa prognosticvalueofthemodifiedatherogenicindexofplasmaduringbodymassreductioninpolishobeseoverweightpeople