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PIXER: an automated particle-selection method based on segmentation using a deep neural network

BACKGROUND: Cryo-electron microscopy (cryo-EM) has become a widely used tool for determining the structures of proteins and macromolecular complexes. To acquire the input for single-particle cryo-EM reconstruction, researchers must select hundreds of thousands of particles from micrographs. As the s...

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Detalles Bibliográficos
Autores principales: Zhang, Jingrong, Wang, Zihao, Chen, Yu, Han, Renmin, Liu, Zhiyong, Sun, Fei, Zhang, Fa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339297/
https://www.ncbi.nlm.nih.gov/pubmed/30658571
http://dx.doi.org/10.1186/s12859-019-2614-y