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Non Secretory Multiple Myeloma With HCV Infection: A Rare Case Entity

Multiple Myeloma is a neoplasm of B cell lineage characterized by excessive proliferation of abnormal plasma cells. It is characterized by a clinical pentad of 1) anemia, 2) a monoclonal protein in the serum or the urine or both, 3) bone leisons and or bone pain, 4) hypercalcemia>11.5g/dl and 5)...

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Autores principales: Puri, Arun, Wadhwa, Heena, Singh, Navtej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Society of Pathology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339487/
https://www.ncbi.nlm.nih.gov/pubmed/30697300
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author Puri, Arun
Wadhwa, Heena
Singh, Navtej
author_facet Puri, Arun
Wadhwa, Heena
Singh, Navtej
author_sort Puri, Arun
collection PubMed
description Multiple Myeloma is a neoplasm of B cell lineage characterized by excessive proliferation of abnormal plasma cells. It is characterized by a clinical pentad of 1) anemia, 2) a monoclonal protein in the serum or the urine or both, 3) bone leisons and or bone pain, 4) hypercalcemia>11.5g/dl and 5) renal insufficiency. Non secretory multiple myeloma is a rare variant of the classic form of multiple myeloma and accounts for 1% to 5 % of all cases of multiple myeloma. The clinical presentation and radiographic findings of non-secretory multiple myeloma and multiple myeloma are the same. The diagnosis of multiple myeloma requires the demonstration of monoclonal gammopathy in the serum or urine. In non-secretory multiple myeloma, however no such gammopathy can be demonstrated, making the diagnosis more difficult. We describe a 60 year old woman who initially presented with back pain which when further investigated by complete blood count revealed hemoglobin of 13g/dl, Total Leukocyte Count of 10,890 and platelet count of 1.5 lac/cmm. Viral markers revealed HCV positive. Hypercalcemia with a serum calcium level of 12.5g/dl was also demonstrated. MRI revealed multiple lytic bony lesions. No monoclonal gammopathy was found in the serum or urine and bone marrow biopsy showed marked plasmacytosis of > 45%. We present a case of Non Secretory multiple myeloma because of its illusive nature and rare entity.
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spelling pubmed-63394872019-01-29 Non Secretory Multiple Myeloma With HCV Infection: A Rare Case Entity Puri, Arun Wadhwa, Heena Singh, Navtej Iran J Pathol Case Report Multiple Myeloma is a neoplasm of B cell lineage characterized by excessive proliferation of abnormal plasma cells. It is characterized by a clinical pentad of 1) anemia, 2) a monoclonal protein in the serum or the urine or both, 3) bone leisons and or bone pain, 4) hypercalcemia>11.5g/dl and 5) renal insufficiency. Non secretory multiple myeloma is a rare variant of the classic form of multiple myeloma and accounts for 1% to 5 % of all cases of multiple myeloma. The clinical presentation and radiographic findings of non-secretory multiple myeloma and multiple myeloma are the same. The diagnosis of multiple myeloma requires the demonstration of monoclonal gammopathy in the serum or urine. In non-secretory multiple myeloma, however no such gammopathy can be demonstrated, making the diagnosis more difficult. We describe a 60 year old woman who initially presented with back pain which when further investigated by complete blood count revealed hemoglobin of 13g/dl, Total Leukocyte Count of 10,890 and platelet count of 1.5 lac/cmm. Viral markers revealed HCV positive. Hypercalcemia with a serum calcium level of 12.5g/dl was also demonstrated. MRI revealed multiple lytic bony lesions. No monoclonal gammopathy was found in the serum or urine and bone marrow biopsy showed marked plasmacytosis of > 45%. We present a case of Non Secretory multiple myeloma because of its illusive nature and rare entity. Iranian Society of Pathology 2018 2018-07-17 /pmc/articles/PMC6339487/ /pubmed/30697300 Text en © 2018, IRANIAN JOURNAL OF PATHOLOGY This is an open-access article distributed under the terms of the Creative Commons Attribution-noncommercial 4.0 International License, (https://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Case Report
Puri, Arun
Wadhwa, Heena
Singh, Navtej
Non Secretory Multiple Myeloma With HCV Infection: A Rare Case Entity
title Non Secretory Multiple Myeloma With HCV Infection: A Rare Case Entity
title_full Non Secretory Multiple Myeloma With HCV Infection: A Rare Case Entity
title_fullStr Non Secretory Multiple Myeloma With HCV Infection: A Rare Case Entity
title_full_unstemmed Non Secretory Multiple Myeloma With HCV Infection: A Rare Case Entity
title_short Non Secretory Multiple Myeloma With HCV Infection: A Rare Case Entity
title_sort non secretory multiple myeloma with hcv infection: a rare case entity
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339487/
https://www.ncbi.nlm.nih.gov/pubmed/30697300
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