Cargando…

Assessment of Micro-vessel Density in Brain Gliomaby CD105 Expression

BACKGROUND & OBJECTIVE: Micro-vascular proliferation is an important histological feature of brain glioma with more vascular proliferation is present in higher grades of glioma. CD 105 is expressed in new actively proliferating and immature endothelial cells in tumor environment and appears to b...

Descripción completa

Detalles Bibliográficos
Autores principales: Saffar, Hiva, Mirzaii, Marzieh, Mirzaian, Elham, Kosari, Farid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Society of Pathology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339494/
https://www.ncbi.nlm.nih.gov/pubmed/30697291
_version_ 1783388650325671936
author Saffar, Hiva
Mirzaii, Marzieh
Mirzaian, Elham
Kosari, Farid
author_facet Saffar, Hiva
Mirzaii, Marzieh
Mirzaian, Elham
Kosari, Farid
author_sort Saffar, Hiva
collection PubMed
description BACKGROUND & OBJECTIVE: Micro-vascular proliferation is an important histological feature of brain glioma with more vascular proliferation is present in higher grades of glioma. CD 105 is expressed in new actively proliferating and immature endothelial cells in tumor environment and appears to be capable to distinguish between malignant neo-vasculature and normal vessels. METHODS: This study was designed to evaluate the Micro-Vessel Density(MVD) in different grades of brain glioma based on CD 105 expression byImmunohistochemistry method to determine whether it can be a helpful marker for rumor grading or not. Paraffin blocks of formalin fixed samples of brain astrocyticglioma were retrieved and IHC was performed using anti-CD105 monoclonal mouse antibody. RESULTS: Total number of 48cases of low and high grade astrocyticgliomas were evaluated.We noted that there was a positive correlation between MVD evaluated by CD105 and tumor grade, meaning that expression was significantly greater in tumors with higher grade (P=0.019). CONCLUSION: We concluded that MVD quantified by CD 105 has positive correlation with tumor grade. Also we think that expression of CD 105 specially in low-grade glioma can serve as a basis for selective treatment option in combination with current standard care.
format Online
Article
Text
id pubmed-6339494
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Iranian Society of Pathology
record_format MEDLINE/PubMed
spelling pubmed-63394942019-01-29 Assessment of Micro-vessel Density in Brain Gliomaby CD105 Expression Saffar, Hiva Mirzaii, Marzieh Mirzaian, Elham Kosari, Farid Iran J Pathol Original Article BACKGROUND & OBJECTIVE: Micro-vascular proliferation is an important histological feature of brain glioma with more vascular proliferation is present in higher grades of glioma. CD 105 is expressed in new actively proliferating and immature endothelial cells in tumor environment and appears to be capable to distinguish between malignant neo-vasculature and normal vessels. METHODS: This study was designed to evaluate the Micro-Vessel Density(MVD) in different grades of brain glioma based on CD 105 expression byImmunohistochemistry method to determine whether it can be a helpful marker for rumor grading or not. Paraffin blocks of formalin fixed samples of brain astrocyticglioma were retrieved and IHC was performed using anti-CD105 monoclonal mouse antibody. RESULTS: Total number of 48cases of low and high grade astrocyticgliomas were evaluated.We noted that there was a positive correlation between MVD evaluated by CD105 and tumor grade, meaning that expression was significantly greater in tumors with higher grade (P=0.019). CONCLUSION: We concluded that MVD quantified by CD 105 has positive correlation with tumor grade. Also we think that expression of CD 105 specially in low-grade glioma can serve as a basis for selective treatment option in combination with current standard care. Iranian Society of Pathology 2018 2018-07-17 /pmc/articles/PMC6339494/ /pubmed/30697291 Text en © 2018, IRANIAN JOURNAL OF PATHOLOGY This is an open-access article distributed under the terms of the Creative Commons Attribution-noncommercial 4.0 International License, (https://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Original Article
Saffar, Hiva
Mirzaii, Marzieh
Mirzaian, Elham
Kosari, Farid
Assessment of Micro-vessel Density in Brain Gliomaby CD105 Expression
title Assessment of Micro-vessel Density in Brain Gliomaby CD105 Expression
title_full Assessment of Micro-vessel Density in Brain Gliomaby CD105 Expression
title_fullStr Assessment of Micro-vessel Density in Brain Gliomaby CD105 Expression
title_full_unstemmed Assessment of Micro-vessel Density in Brain Gliomaby CD105 Expression
title_short Assessment of Micro-vessel Density in Brain Gliomaby CD105 Expression
title_sort assessment of micro-vessel density in brain gliomaby cd105 expression
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339494/
https://www.ncbi.nlm.nih.gov/pubmed/30697291
work_keys_str_mv AT saffarhiva assessmentofmicrovesseldensityinbraingliomabycd105expression
AT mirzaiimarzieh assessmentofmicrovesseldensityinbraingliomabycd105expression
AT mirzaianelham assessmentofmicrovesseldensityinbraingliomabycd105expression
AT kosarifarid assessmentofmicrovesseldensityinbraingliomabycd105expression