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CRISPR/Cas9-mediated deletion of the Wiskott-Aldrich syndrome locus causes actin cytoskeleton disorganization in murine erythroleukemia cells

Wiskott-Aldrich syndrome (WAS) is a recessive X-linked inmmunodeficiency caused by loss-of-function mutations in the gene encoding the WAS protein (WASp). WASp plays an important role in the polymerization of the actin cytoskeleton in hematopoietic cells through activation of the Arp2/3 complex. In...

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Detalles Bibliográficos
Autores principales:	Fernández-Calleja, Vanessa, Fernández-Nestosa, María-José, Hernández, Pablo, Schvartzman, Jorge B., Krimer, Dora B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2019
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339507/ https://www.ncbi.nlm.nih.gov/pubmed/30671311 http://dx.doi.org/10.7717/peerj.6284

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