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Mapping the Positive and Negative Syndrome Scale scores to EQ-5D-5L and SF-6D utility scores in patients with schizophrenia

OBJECTIVE: The current study aims to map the Positive and Negative Syndrome Scale (PANSS) onto the five-level EuroQol five-dimensional (EQ-5D-5L) and Short Form six-dimensional (SF-6D) utility scores for patients with schizophrenia. METHODS: A total of 239 participants with schizophrenia spectrum di...

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Autores principales: Abdin, Edimansyah, Chong, Siow Ann, Seow, Esmond, Verma, Swapna, Tan, Kelvin Bryan, Subramaniam, Mythily
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339678/
https://www.ncbi.nlm.nih.gov/pubmed/30382480
http://dx.doi.org/10.1007/s11136-018-2037-7
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author Abdin, Edimansyah
Chong, Siow Ann
Seow, Esmond
Verma, Swapna
Tan, Kelvin Bryan
Subramaniam, Mythily
author_facet Abdin, Edimansyah
Chong, Siow Ann
Seow, Esmond
Verma, Swapna
Tan, Kelvin Bryan
Subramaniam, Mythily
author_sort Abdin, Edimansyah
collection PubMed
description OBJECTIVE: The current study aims to map the Positive and Negative Syndrome Scale (PANSS) onto the five-level EuroQol five-dimensional (EQ-5D-5L) and Short Form six-dimensional (SF-6D) utility scores for patients with schizophrenia. METHODS: A total of 239 participants with schizophrenia spectrum disorder were recruited from a tertiary psychiatric hospital in Singapore. Ordinary least squares (OLS), censored least absolute deviations and Tobit regression methods were employed to estimate utility scores from the EQ-5D-5L and SF-6D. Model selection of the 18 regression models (three regression methods × six model specifications) was primarily determined by the smallest mean absolute error and mean square error, and the largest R(2) and adjusted R(2). RESULTS: The mean age of the sample was 39.7 years (SD = 10.3). The mean EQ-5D-5L and SF-6D utility scores were 0.81 and 0.68, respectively. The EQ-5D-5L utility scores were best predicted by the OLS regression model consisting of three PANSS subscales, i.e. positive, negative and general psychopathology symptoms, and covariates including age and gender. The SF-6D was best predicted by OLS regression model consisting of five PANSS subscales, i.e. positive, negative, excitement, depression and cognitive subscales. CONCLUSION: The current study provides important evidence to clinicians and researchers on mapping algorithms for converting PANSS scores into utility scores that can be easily applicable for cost–utility analysis when EQ-5D-5L and SF-6D data are not available for patients with schizophrenia spectrum disorder in Singapore. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11136-018-2037-7) contains supplementary material, which is available to authorized users.
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spelling pubmed-63396782019-02-01 Mapping the Positive and Negative Syndrome Scale scores to EQ-5D-5L and SF-6D utility scores in patients with schizophrenia Abdin, Edimansyah Chong, Siow Ann Seow, Esmond Verma, Swapna Tan, Kelvin Bryan Subramaniam, Mythily Qual Life Res Article OBJECTIVE: The current study aims to map the Positive and Negative Syndrome Scale (PANSS) onto the five-level EuroQol five-dimensional (EQ-5D-5L) and Short Form six-dimensional (SF-6D) utility scores for patients with schizophrenia. METHODS: A total of 239 participants with schizophrenia spectrum disorder were recruited from a tertiary psychiatric hospital in Singapore. Ordinary least squares (OLS), censored least absolute deviations and Tobit regression methods were employed to estimate utility scores from the EQ-5D-5L and SF-6D. Model selection of the 18 regression models (three regression methods × six model specifications) was primarily determined by the smallest mean absolute error and mean square error, and the largest R(2) and adjusted R(2). RESULTS: The mean age of the sample was 39.7 years (SD = 10.3). The mean EQ-5D-5L and SF-6D utility scores were 0.81 and 0.68, respectively. The EQ-5D-5L utility scores were best predicted by the OLS regression model consisting of three PANSS subscales, i.e. positive, negative and general psychopathology symptoms, and covariates including age and gender. The SF-6D was best predicted by OLS regression model consisting of five PANSS subscales, i.e. positive, negative, excitement, depression and cognitive subscales. CONCLUSION: The current study provides important evidence to clinicians and researchers on mapping algorithms for converting PANSS scores into utility scores that can be easily applicable for cost–utility analysis when EQ-5D-5L and SF-6D data are not available for patients with schizophrenia spectrum disorder in Singapore. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11136-018-2037-7) contains supplementary material, which is available to authorized users. Springer International Publishing 2018-10-31 2019 /pmc/articles/PMC6339678/ /pubmed/30382480 http://dx.doi.org/10.1007/s11136-018-2037-7 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Abdin, Edimansyah
Chong, Siow Ann
Seow, Esmond
Verma, Swapna
Tan, Kelvin Bryan
Subramaniam, Mythily
Mapping the Positive and Negative Syndrome Scale scores to EQ-5D-5L and SF-6D utility scores in patients with schizophrenia
title Mapping the Positive and Negative Syndrome Scale scores to EQ-5D-5L and SF-6D utility scores in patients with schizophrenia
title_full Mapping the Positive and Negative Syndrome Scale scores to EQ-5D-5L and SF-6D utility scores in patients with schizophrenia
title_fullStr Mapping the Positive and Negative Syndrome Scale scores to EQ-5D-5L and SF-6D utility scores in patients with schizophrenia
title_full_unstemmed Mapping the Positive and Negative Syndrome Scale scores to EQ-5D-5L and SF-6D utility scores in patients with schizophrenia
title_short Mapping the Positive and Negative Syndrome Scale scores to EQ-5D-5L and SF-6D utility scores in patients with schizophrenia
title_sort mapping the positive and negative syndrome scale scores to eq-5d-5l and sf-6d utility scores in patients with schizophrenia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339678/
https://www.ncbi.nlm.nih.gov/pubmed/30382480
http://dx.doi.org/10.1007/s11136-018-2037-7
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