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“Bisphenol a: an emerging threat to male fertility”
BACKGROUND: Among the factors causing male infertility, one of the most debated is the exposure to environmental contaminants. Recently, the chemical compound Bisphenol A (BPA) has drawn attention from the reproductive science community, due to its ubiquitous presence in day-to-day life. Its toxic a...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339693/ https://www.ncbi.nlm.nih.gov/pubmed/30660193 http://dx.doi.org/10.1186/s12958-018-0447-6 |
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author | Cariati, Federica D’Uonno, Nadja Borrillo, Francesca Iervolino, Stefania Galdiero, Giacomo Tomaiuolo, Rossella |
author_facet | Cariati, Federica D’Uonno, Nadja Borrillo, Francesca Iervolino, Stefania Galdiero, Giacomo Tomaiuolo, Rossella |
author_sort | Cariati, Federica |
collection | PubMed |
description | BACKGROUND: Among the factors causing male infertility, one of the most debated is the exposure to environmental contaminants. Recently, the chemical compound Bisphenol A (BPA) has drawn attention from the reproductive science community, due to its ubiquitous presence in day-to-day life. Its toxic action appears to mainly affect the male reproductive system, directly impacting male fertility. MAIN: The purpose of this review is to investigate current research data on BPA, providing an overview of the findings obtained from studies in animal and human models, as well as on its supposed mechanisms of action. CONCLUSION: A clear understanding of BPA action mechanisms, as well as the presumed risks deriving from its exposure, is becoming crucial to preserve male fertility. The development and validation of methodologies to detect BPA toxic effects on reproductive organs can provide greater awareness of the potential threat that this chemical represents. |
format | Online Article Text |
id | pubmed-6339693 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-63396932019-01-24 “Bisphenol a: an emerging threat to male fertility” Cariati, Federica D’Uonno, Nadja Borrillo, Francesca Iervolino, Stefania Galdiero, Giacomo Tomaiuolo, Rossella Reprod Biol Endocrinol Review BACKGROUND: Among the factors causing male infertility, one of the most debated is the exposure to environmental contaminants. Recently, the chemical compound Bisphenol A (BPA) has drawn attention from the reproductive science community, due to its ubiquitous presence in day-to-day life. Its toxic action appears to mainly affect the male reproductive system, directly impacting male fertility. MAIN: The purpose of this review is to investigate current research data on BPA, providing an overview of the findings obtained from studies in animal and human models, as well as on its supposed mechanisms of action. CONCLUSION: A clear understanding of BPA action mechanisms, as well as the presumed risks deriving from its exposure, is becoming crucial to preserve male fertility. The development and validation of methodologies to detect BPA toxic effects on reproductive organs can provide greater awareness of the potential threat that this chemical represents. BioMed Central 2019-01-20 /pmc/articles/PMC6339693/ /pubmed/30660193 http://dx.doi.org/10.1186/s12958-018-0447-6 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Cariati, Federica D’Uonno, Nadja Borrillo, Francesca Iervolino, Stefania Galdiero, Giacomo Tomaiuolo, Rossella “Bisphenol a: an emerging threat to male fertility” |
title | “Bisphenol a: an emerging threat to male fertility” |
title_full | “Bisphenol a: an emerging threat to male fertility” |
title_fullStr | “Bisphenol a: an emerging threat to male fertility” |
title_full_unstemmed | “Bisphenol a: an emerging threat to male fertility” |
title_short | “Bisphenol a: an emerging threat to male fertility” |
title_sort | “bisphenol a: an emerging threat to male fertility” |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339693/ https://www.ncbi.nlm.nih.gov/pubmed/30660193 http://dx.doi.org/10.1186/s12958-018-0447-6 |
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