Autophagy Regulated by Gain of Function Mutant p53 Enhances Proteasomal Inhibitor-Mediated Cell Death through Induction of ROS and ERK in Lung Cancer Cells

Mutations in p53, especially gain of function (GOF) mutations, are highly frequent in lung cancers and are known to facilitate tumor aggressiveness. Yet, the links between mutant GOF-p53 and lung cancers are not well established. In the present study, we set to examine how we can better sensitize re...

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Detalles Bibliográficos
Autores principales: Saini, Heena, Hakeem, Ifrah, Mukherjee, Sudeshna, Chowdhury, Shibasish, Chowdhury, Rajdeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339715/
https://www.ncbi.nlm.nih.gov/pubmed/30723502
http://dx.doi.org/10.1155/2019/6164807

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339715/
https://www.ncbi.nlm.nih.gov/pubmed/30723502
http://dx.doi.org/10.1155/2019/6164807

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