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Anthranilic Acid Inhibitors of Undecaprenyl Pyrophosphate Synthase (UppS), an Essential Enzyme for Bacterial Cell Wall Biosynthesis

We report the successful implementation of virtual screening in the discovery of new inhibitors of undecaprenyl pyrophosphate synthase (UppS) from Escherichia coli. UppS is an essential enzyme in the biosynthesis of bacterial cell wall. It catalyzes the condensation of farnesyl pyrophosphate (FPP) w...

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Detalles Bibliográficos
Autores principales:	Jukič, Marko, Rožman, Kaja, Sova, Matej, Barreteau, Hélène, Gobec, Stanislav
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339874/ https://www.ncbi.nlm.nih.gov/pubmed/30692977 http://dx.doi.org/10.3389/fmicb.2018.03322

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