Anti‐IL‐7 receptor α monoclonal antibody (GSK2618960) in healthy subjects – a randomized, double‐blind, placebo‐controlled study

AIM: Interleukin (IL)‐7 signalling modulates T cell activity and is implicated in numerous autoimmune diseases. The present study investigated the safety, pharmacokinetics, target engagement, pharmacodynamics and immunogenicity of GSK2618960, an IL‐7 receptor‐α subunit (CD127) monoclonal antibody. M...

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Detalles Bibliográficos
Autores principales: Ellis, Joanne, van Maurik, Andre, Fortunato, Lea, Gisbert, Sophie, Chen, Keguan, Schwartz, Ann, McHugh, Simon, Want, Andrew, Santos Franco, Sara, Oliveira, Joao‐Joaquim, Price, Jeffrey, Coles, Alasdair, Brown, Kim, Su, Donggang, Craigen, Jenny L., Yang, Jiansong, Brett, Sara, Davis, Bill, Cheriyan, Joseph, Kousin‐Ezewu, Onajite, Gray, Frank, Thompson, Paul W., Fernando, Disala
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339973/
https://www.ncbi.nlm.nih.gov/pubmed/30161291
http://dx.doi.org/10.1111/bcp.13748

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