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Cocaine, nicotine, and their conditioned contexts enhance consolidation of object memory in rats

To test the hypothesis that drugs of abuse and their conditioned stimuli (CSs) enhance memory consolidation, the effects of post-training exposure to cocaine and nicotine were compared to the effects of post-training exposure to contextual stimuli that were paired with the effects of these drugs. Us...

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Autores principales: Wolter, Michael, Huff, Ethan, Speigel, Talia, Winters, Boyer D., Leri, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340119/
https://www.ncbi.nlm.nih.gov/pubmed/30651377
http://dx.doi.org/10.1101/lm.048579.118
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author Wolter, Michael
Huff, Ethan
Speigel, Talia
Winters, Boyer D.
Leri, Francesco
author_facet Wolter, Michael
Huff, Ethan
Speigel, Talia
Winters, Boyer D.
Leri, Francesco
author_sort Wolter, Michael
collection PubMed
description To test the hypothesis that drugs of abuse and their conditioned stimuli (CSs) enhance memory consolidation, the effects of post-training exposure to cocaine and nicotine were compared to the effects of post-training exposure to contextual stimuli that were paired with the effects of these drugs. Using the object recognition (OR) task, it was first demonstrated that both 10 and 20 mg/kg cocaine, and 0.2 and 0.4 mg/kg nicotine, enhanced recognition memory when administered immediately after, but not 6 h after the sample phase. To establish the drug CSs, rats were confined for 2 h in a chamber (the CS+) after injections of 20 mg/kg cocaine, or 0.4 mg/kg nicotine, and in another chamber (the CS−) after injections of vehicle. This was repeated over 10 d (5 drug/CS+ and 5 vehicle/CS− pairings in total). At the end of this conditioning period, when tested in a drug-free state, rats displayed conditioned hyperactivity in the CS+ relative to the CS−. More important, immediate, but not delayed, post-sample exposure to the cocaine CS+, or nicotine CS+, enhanced OR memory. Therefore, this study reports for the first time that contextual stimuli paired with cocaine and nicotine, like the drugs themselves, have the ability to enhance memory consolidation.
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spelling pubmed-63401192019-02-03 Cocaine, nicotine, and their conditioned contexts enhance consolidation of object memory in rats Wolter, Michael Huff, Ethan Speigel, Talia Winters, Boyer D. Leri, Francesco Learn Mem Research To test the hypothesis that drugs of abuse and their conditioned stimuli (CSs) enhance memory consolidation, the effects of post-training exposure to cocaine and nicotine were compared to the effects of post-training exposure to contextual stimuli that were paired with the effects of these drugs. Using the object recognition (OR) task, it was first demonstrated that both 10 and 20 mg/kg cocaine, and 0.2 and 0.4 mg/kg nicotine, enhanced recognition memory when administered immediately after, but not 6 h after the sample phase. To establish the drug CSs, rats were confined for 2 h in a chamber (the CS+) after injections of 20 mg/kg cocaine, or 0.4 mg/kg nicotine, and in another chamber (the CS−) after injections of vehicle. This was repeated over 10 d (5 drug/CS+ and 5 vehicle/CS− pairings in total). At the end of this conditioning period, when tested in a drug-free state, rats displayed conditioned hyperactivity in the CS+ relative to the CS−. More important, immediate, but not delayed, post-sample exposure to the cocaine CS+, or nicotine CS+, enhanced OR memory. Therefore, this study reports for the first time that contextual stimuli paired with cocaine and nicotine, like the drugs themselves, have the ability to enhance memory consolidation. Cold Spring Harbor Laboratory Press 2019-02 /pmc/articles/PMC6340119/ /pubmed/30651377 http://dx.doi.org/10.1101/lm.048579.118 Text en © 2019 Wolter et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by/4.0/ This article, published in Learning & Memory, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.
spellingShingle Research
Wolter, Michael
Huff, Ethan
Speigel, Talia
Winters, Boyer D.
Leri, Francesco
Cocaine, nicotine, and their conditioned contexts enhance consolidation of object memory in rats
title Cocaine, nicotine, and their conditioned contexts enhance consolidation of object memory in rats
title_full Cocaine, nicotine, and their conditioned contexts enhance consolidation of object memory in rats
title_fullStr Cocaine, nicotine, and their conditioned contexts enhance consolidation of object memory in rats
title_full_unstemmed Cocaine, nicotine, and their conditioned contexts enhance consolidation of object memory in rats
title_short Cocaine, nicotine, and their conditioned contexts enhance consolidation of object memory in rats
title_sort cocaine, nicotine, and their conditioned contexts enhance consolidation of object memory in rats
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340119/
https://www.ncbi.nlm.nih.gov/pubmed/30651377
http://dx.doi.org/10.1101/lm.048579.118
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