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Circular RNA 100146 functions as an oncogene through direct binding to miR-361-3p and miR-615-5p in non-small cell lung cancer

Circular RNAs are widely expressed in eukaryotic cells and associated with cancer. However, limited studies to date have focused on the potential role of circRNAs in progression of lung cancer. Data from the current investigation showed that circRNA 100146 is highly expressed in non-small cell lung...

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Autores principales: Chen, Lijian, Nan, Aruo, Zhang, Nan, Jia, Yangyang, Li, Xin, Ling, Yihui, Dai, Jiabin, Zhang, Shaozhu, Yang, Qiaoyuan, Yi, Yanni, Jiang, Yiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340182/
https://www.ncbi.nlm.nih.gov/pubmed/30665425
http://dx.doi.org/10.1186/s12943-019-0943-0
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author Chen, Lijian
Nan, Aruo
Zhang, Nan
Jia, Yangyang
Li, Xin
Ling, Yihui
Dai, Jiabin
Zhang, Shaozhu
Yang, Qiaoyuan
Yi, Yanni
Jiang, Yiguo
author_facet Chen, Lijian
Nan, Aruo
Zhang, Nan
Jia, Yangyang
Li, Xin
Ling, Yihui
Dai, Jiabin
Zhang, Shaozhu
Yang, Qiaoyuan
Yi, Yanni
Jiang, Yiguo
author_sort Chen, Lijian
collection PubMed
description Circular RNAs are widely expressed in eukaryotic cells and associated with cancer. However, limited studies to date have focused on the potential role of circRNAs in progression of lung cancer. Data from the current investigation showed that circRNA 100146 is highly expressed in non-small cell lung cancer (NSCLC) cell lines and the chemically induced malignant transformed bronchial cell line, 16HBE-T, as well as 40 paired tissue samples of NSCLC. Suppression of circRNA 100146 inhibited the proliferation and invasion of cells and promoted apoptosis. Furthermore, circRNA 100146 could interact with splicing factors and bind miR-361-3p and miR-615-5p to regulate multiple downstream mRNAs. Our collective findings support a role of circRNA 100146 in the development of NSCLC and further demonstrate endogenous competition among circRNA 100146, SF3B3 and miRNAs, providing novel insights into the mechanisms underlying non-small cell lung cancer. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12943-019-0943-0) contains supplementary material, which is available to authorized users.
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spelling pubmed-63401822019-01-24 Circular RNA 100146 functions as an oncogene through direct binding to miR-361-3p and miR-615-5p in non-small cell lung cancer Chen, Lijian Nan, Aruo Zhang, Nan Jia, Yangyang Li, Xin Ling, Yihui Dai, Jiabin Zhang, Shaozhu Yang, Qiaoyuan Yi, Yanni Jiang, Yiguo Mol Cancer Letter to the Editor Circular RNAs are widely expressed in eukaryotic cells and associated with cancer. However, limited studies to date have focused on the potential role of circRNAs in progression of lung cancer. Data from the current investigation showed that circRNA 100146 is highly expressed in non-small cell lung cancer (NSCLC) cell lines and the chemically induced malignant transformed bronchial cell line, 16HBE-T, as well as 40 paired tissue samples of NSCLC. Suppression of circRNA 100146 inhibited the proliferation and invasion of cells and promoted apoptosis. Furthermore, circRNA 100146 could interact with splicing factors and bind miR-361-3p and miR-615-5p to regulate multiple downstream mRNAs. Our collective findings support a role of circRNA 100146 in the development of NSCLC and further demonstrate endogenous competition among circRNA 100146, SF3B3 and miRNAs, providing novel insights into the mechanisms underlying non-small cell lung cancer. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12943-019-0943-0) contains supplementary material, which is available to authorized users. BioMed Central 2019-01-21 /pmc/articles/PMC6340182/ /pubmed/30665425 http://dx.doi.org/10.1186/s12943-019-0943-0 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Chen, Lijian
Nan, Aruo
Zhang, Nan
Jia, Yangyang
Li, Xin
Ling, Yihui
Dai, Jiabin
Zhang, Shaozhu
Yang, Qiaoyuan
Yi, Yanni
Jiang, Yiguo
Circular RNA 100146 functions as an oncogene through direct binding to miR-361-3p and miR-615-5p in non-small cell lung cancer
title Circular RNA 100146 functions as an oncogene through direct binding to miR-361-3p and miR-615-5p in non-small cell lung cancer
title_full Circular RNA 100146 functions as an oncogene through direct binding to miR-361-3p and miR-615-5p in non-small cell lung cancer
title_fullStr Circular RNA 100146 functions as an oncogene through direct binding to miR-361-3p and miR-615-5p in non-small cell lung cancer
title_full_unstemmed Circular RNA 100146 functions as an oncogene through direct binding to miR-361-3p and miR-615-5p in non-small cell lung cancer
title_short Circular RNA 100146 functions as an oncogene through direct binding to miR-361-3p and miR-615-5p in non-small cell lung cancer
title_sort circular rna 100146 functions as an oncogene through direct binding to mir-361-3p and mir-615-5p in non-small cell lung cancer
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340182/
https://www.ncbi.nlm.nih.gov/pubmed/30665425
http://dx.doi.org/10.1186/s12943-019-0943-0
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