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The mode of action of anticholinergics in asthma

Acetylcholine binds to muscarinic receptors to play a key role in the pathophysiology of asthma, leading to bronchoconstriction, increased mucus secretion, inflammation and airway remodelling. Anticholinergics are muscarinic receptor antagonists that are used in the treatment of chronic obstructive...

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Detalles Bibliográficos
Autores principales: Gosens, Reinoud, Gross, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340638/
https://www.ncbi.nlm.nih.gov/pubmed/30115613
http://dx.doi.org/10.1183/13993003.01247-2017
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author Gosens, Reinoud
Gross, Nicholas
author_facet Gosens, Reinoud
Gross, Nicholas
author_sort Gosens, Reinoud
collection PubMed
description Acetylcholine binds to muscarinic receptors to play a key role in the pathophysiology of asthma, leading to bronchoconstriction, increased mucus secretion, inflammation and airway remodelling. Anticholinergics are muscarinic receptor antagonists that are used in the treatment of chronic obstructive pulmonary disease and asthma. Recent in vivo and in vitro data have increased our understanding of how acetylcholine contributes to the disease manifestations of asthma, as well as elucidating the mechanism of action of anticholinergics. This review assesses the latest literature on acetylcholine in asthma pathophysiology, with a closer look at its role in airway inflammation and remodelling. New insights into the mechanism of action of anticholinergics, their effects on airway remodelling, and a review of the efficacy and safety of long-acting anticholinergics in asthma treatment will also be covered, including a summary of the latest clinical trial data.
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spelling pubmed-63406382019-01-25 The mode of action of anticholinergics in asthma Gosens, Reinoud Gross, Nicholas Eur Respir J Back to Basics Acetylcholine binds to muscarinic receptors to play a key role in the pathophysiology of asthma, leading to bronchoconstriction, increased mucus secretion, inflammation and airway remodelling. Anticholinergics are muscarinic receptor antagonists that are used in the treatment of chronic obstructive pulmonary disease and asthma. Recent in vivo and in vitro data have increased our understanding of how acetylcholine contributes to the disease manifestations of asthma, as well as elucidating the mechanism of action of anticholinergics. This review assesses the latest literature on acetylcholine in asthma pathophysiology, with a closer look at its role in airway inflammation and remodelling. New insights into the mechanism of action of anticholinergics, their effects on airway remodelling, and a review of the efficacy and safety of long-acting anticholinergics in asthma treatment will also be covered, including a summary of the latest clinical trial data. European Respiratory Society 2018-10-04 /pmc/articles/PMC6340638/ /pubmed/30115613 http://dx.doi.org/10.1183/13993003.01247-2017 Text en Copyright ©ERS 2018 http://creativecommons.org/licenses/by-nc/4.0/ This ERJ Open article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
spellingShingle Back to Basics
Gosens, Reinoud
Gross, Nicholas
The mode of action of anticholinergics in asthma
title The mode of action of anticholinergics in asthma
title_full The mode of action of anticholinergics in asthma
title_fullStr The mode of action of anticholinergics in asthma
title_full_unstemmed The mode of action of anticholinergics in asthma
title_short The mode of action of anticholinergics in asthma
title_sort mode of action of anticholinergics in asthma
topic Back to Basics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340638/
https://www.ncbi.nlm.nih.gov/pubmed/30115613
http://dx.doi.org/10.1183/13993003.01247-2017
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