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The N(6)-Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy
BACKGROUND: N(6)-Methyladenosine (m6A) methylation is the most prevalent internal posttranscriptional modification on mammalian mRNA. The role of m6A mRNA methylation in the heart is not known. METHODS: To determine the role of m6A methylation in the heart, we isolated primary cardiomyocytes and per...
Autores principales: | Dorn, Lisa E., Lasman, Lior, Chen, Jing, Xu, Xianyao, Hund, Thomas J., Medvedovic, Mario, Hanna, Jacob H., van Berlo, Jop H., Accornero, Federica |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340720/ https://www.ncbi.nlm.nih.gov/pubmed/30586742 http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036146 |
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