The Ca(2+) sensor STIM1 regulates type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum

STING is an endoplasmic reticulum (ER) signaling adaptor that is essential for the type I Interferon response to DNA pathogens. Aberrant activation of STING is linked to the pathology of autoimmune and autoinflammatory diseases. The rate-limiting step for the activation of STING is its translocation...

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Detalles Bibliográficos
Autores principales: Srikanth, Sonal, Woo, Jin Seok, Wu, Beibei, El-Sherbiny, Yasser M., Leung, Jennifer, Chupradit, Koollawat, Rice, Laura, Seo, Gil Ju, Calmettes, Guillaume, Ramakrishna, Chandran, Cantin, Edouard, An, Dong Sung, Sun, Ren, Wu, Ting-Ting, Jung, Jae U., Savic, Sinisa, Gwack, Yousang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340781/
https://www.ncbi.nlm.nih.gov/pubmed/30643259
http://dx.doi.org/10.1038/s41590-018-0287-8

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