Targeting protein kinase CK2 and CDK4/6 pathways with a multi-kinase inhibitor ON108110 suppresses pro-survival signaling and growth in mantle cell lymphoma and T-acute lymphoblastic leukemia

Overexpression and constitutive activation of CYCLIN D1 and Casein Kinase 2 are common features of many hematologic malignancies, including mantle cell lymphoma (MCL) and leukemias such as T-cell acute lymphoblastic leukemia (T-ALL). Although both CK2 and CDK4 inhibitors have shown promising results...

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Detalles Bibliográficos
Autores principales: Padgaonkar, Amol, Rechkoblit, Olga, Vasquez-Del Carpio, Rodgrigo, Pallela, Venkat, Venkata Subbaiah, DRC, Cosenza, Stephen C., Baker, Stacey J., Ramana Reddy, M.V., Aggarwal, Aneel, Reddy, E. Premkumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340882/
https://www.ncbi.nlm.nih.gov/pubmed/30701029
http://dx.doi.org/10.18632/oncotarget.26514

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