The Cdc48 unfoldase prepares well-folded protein substrates for degradation by the 26S proteasome

Cdc48/p97 is an essential and highly conserved AAA+ ATPase that uses its protein-unfoldase activity to extract ubiquitinated polypeptides from macromolecular complexes and membranes. This motor has also been implicated in protein-degradation pathways, yet its exact role in acting upstream of the 26S...

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Detalles Bibliográficos
Autores principales: Olszewski, Michal M., Williams, Cameron, Dong, Ken C., Martin, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340886/
https://www.ncbi.nlm.nih.gov/pubmed/30675527
http://dx.doi.org/10.1038/s42003-019-0283-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340886/
https://www.ncbi.nlm.nih.gov/pubmed/30675527
http://dx.doi.org/10.1038/s42003-019-0283-z

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