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The Cdc48 unfoldase prepares well-folded protein substrates for degradation by the 26S proteasome

Cdc48/p97 is an essential and highly conserved AAA+ ATPase that uses its protein-unfoldase activity to extract ubiquitinated polypeptides from macromolecular complexes and membranes. This motor has also been implicated in protein-degradation pathways, yet its exact role in acting upstream of the 26S...

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Detalles Bibliográficos
Autores principales:	Olszewski, Michal M., Williams, Cameron, Dong, Ken C., Martin, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340886/ https://www.ncbi.nlm.nih.gov/pubmed/30675527 http://dx.doi.org/10.1038/s42003-019-0283-z

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