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Correlation Between Thymus Radiology and Myasthenia Gravis in Clinical Practice
Background: The ability to distinguish between a normal thymus, thymic hyperplasia, and thymoma should aid in clinical management and decision making for patients with myasthenia gravis (MG). We sought to determine the accuracy of routine radiological examinations in predicting thymic pathology. Met...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340958/ https://www.ncbi.nlm.nih.gov/pubmed/30697185 http://dx.doi.org/10.3389/fneur.2018.01173 |
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author | Luo, Huan Xie, Shanshan Ma, Chao Zhang, Wenqiang Tschöpe, Carsten Fa, Xianen Cheng, Jingliang Cao, Jing |
author_facet | Luo, Huan Xie, Shanshan Ma, Chao Zhang, Wenqiang Tschöpe, Carsten Fa, Xianen Cheng, Jingliang Cao, Jing |
author_sort | Luo, Huan |
collection | PubMed |
description | Background: The ability to distinguish between a normal thymus, thymic hyperplasia, and thymoma should aid in clinical management and decision making for patients with myasthenia gravis (MG). We sought to determine the accuracy of routine radiological examinations in predicting thymic pathology. Methods: We retrospectively analyzed the records of patients with MG who had undergone thymectomy from the Second Affiliated Hospital of Zhengzhou University. Each patient received at least one initial radiological diagnosis and one histological diagnosis, and the patients were classified into the all-patient, CT, contrast CT, and MRI groups. The sensitivity, accuracy and specificity of each group were calculated for different histological types. Results: This study included 114 patients. All sensitivity, specificity and accuracy values except for sensitivity to hyperplasia in each group for different histological types were satisfactory. MRI had higher sensitivity (68.4, 95% CI: 43.5–87.4%) to histological hyperplasia than did CT (14.3, 95% CI: 0.4–57.9%) and contrast CT (26.7, 95% CI: 7.8–55.1%). Contrast CT had higher specificity (97.9, 95% CI: 88.9–99.95%) for histological hyperplasia than did MRI (88.5, 95% CI: 69.9–97.6%). Discussion: For patients with MG, CT, contrast CT, and MRI examinations can effectively identify thymoma. Additionally, compared with CT or contrast CT, MRI may have a stronger ability to distinguish thymoma and detect hyperplasia. |
format | Online Article Text |
id | pubmed-6340958 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63409582019-01-29 Correlation Between Thymus Radiology and Myasthenia Gravis in Clinical Practice Luo, Huan Xie, Shanshan Ma, Chao Zhang, Wenqiang Tschöpe, Carsten Fa, Xianen Cheng, Jingliang Cao, Jing Front Neurol Neurology Background: The ability to distinguish between a normal thymus, thymic hyperplasia, and thymoma should aid in clinical management and decision making for patients with myasthenia gravis (MG). We sought to determine the accuracy of routine radiological examinations in predicting thymic pathology. Methods: We retrospectively analyzed the records of patients with MG who had undergone thymectomy from the Second Affiliated Hospital of Zhengzhou University. Each patient received at least one initial radiological diagnosis and one histological diagnosis, and the patients were classified into the all-patient, CT, contrast CT, and MRI groups. The sensitivity, accuracy and specificity of each group were calculated for different histological types. Results: This study included 114 patients. All sensitivity, specificity and accuracy values except for sensitivity to hyperplasia in each group for different histological types were satisfactory. MRI had higher sensitivity (68.4, 95% CI: 43.5–87.4%) to histological hyperplasia than did CT (14.3, 95% CI: 0.4–57.9%) and contrast CT (26.7, 95% CI: 7.8–55.1%). Contrast CT had higher specificity (97.9, 95% CI: 88.9–99.95%) for histological hyperplasia than did MRI (88.5, 95% CI: 69.9–97.6%). Discussion: For patients with MG, CT, contrast CT, and MRI examinations can effectively identify thymoma. Additionally, compared with CT or contrast CT, MRI may have a stronger ability to distinguish thymoma and detect hyperplasia. Frontiers Media S.A. 2019-01-15 /pmc/articles/PMC6340958/ /pubmed/30697185 http://dx.doi.org/10.3389/fneur.2018.01173 Text en Copyright © 2019 Luo, Xie, Ma, Zhang, Tschöpe, Fa, Cheng and Cao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Luo, Huan Xie, Shanshan Ma, Chao Zhang, Wenqiang Tschöpe, Carsten Fa, Xianen Cheng, Jingliang Cao, Jing Correlation Between Thymus Radiology and Myasthenia Gravis in Clinical Practice |
title | Correlation Between Thymus Radiology and Myasthenia Gravis in Clinical Practice |
title_full | Correlation Between Thymus Radiology and Myasthenia Gravis in Clinical Practice |
title_fullStr | Correlation Between Thymus Radiology and Myasthenia Gravis in Clinical Practice |
title_full_unstemmed | Correlation Between Thymus Radiology and Myasthenia Gravis in Clinical Practice |
title_short | Correlation Between Thymus Radiology and Myasthenia Gravis in Clinical Practice |
title_sort | correlation between thymus radiology and myasthenia gravis in clinical practice |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340958/ https://www.ncbi.nlm.nih.gov/pubmed/30697185 http://dx.doi.org/10.3389/fneur.2018.01173 |
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