The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation

Regulatory T (Treg) cells control self-tolerance, inflammatory responses and tissue homeostasis. In mature Treg cells, continued expression of FOXP3 maintains lineage identity, while T cell receptor (TCR) signaling and interleukin-2 (IL-2)/STAT5 activation support the suppressive effector function o...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Bing, Salgado, Oscar C., Singh, Sangya, Hippen, Keli L., Maynard, Jason C., Burlingame, Alma L., Ball, Lauren E., Blazar, Bruce R., Farrar, Michael A., Hogquist, Kristin A., Ruan, Hai-Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341091/
https://www.ncbi.nlm.nih.gov/pubmed/30664665
http://dx.doi.org/10.1038/s41467-019-08300-3

Ejemplares similares

Ejemplares similares