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Preventive effects of combinative natural foods produced by elite crop varieties rich in anticancer effects on N‐nitrosodiethylamine‐induced hepatocellular carcinoma in rats
The World Cancer Research Fund International has released 32 anticancer effects (ACEs) that targeted every stage of cancer processes. Thus, we designed two formulas of natural food combination Diet I and Diet II, mainly produced by elite crop varieties rich in ACEs with different mixture ratios, and...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341211/ https://www.ncbi.nlm.nih.gov/pubmed/30680188 http://dx.doi.org/10.1002/fsn3.896 |
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author | Zheng, Jingui He, Jun Liao, Sufeng Cheng, Zuxin Lin, Jinke Huang, Ke Li, Xiaocen Zheng, Kaibin Chen, Xuanyang Lin, Lihui Xia, Fagang Liu, Jianghong Xu, Ming Chen, Tuansheng Huang, Xinying Cao, Xiaohua Yang, Zhijian |
author_facet | Zheng, Jingui He, Jun Liao, Sufeng Cheng, Zuxin Lin, Jinke Huang, Ke Li, Xiaocen Zheng, Kaibin Chen, Xuanyang Lin, Lihui Xia, Fagang Liu, Jianghong Xu, Ming Chen, Tuansheng Huang, Xinying Cao, Xiaohua Yang, Zhijian |
author_sort | Zheng, Jingui |
collection | PubMed |
description | The World Cancer Research Fund International has released 32 anticancer effects (ACEs) that targeted every stage of cancer processes. Thus, we designed two formulas of natural food combination Diet I and Diet II, mainly produced by elite crop varieties rich in ACEs with different mixture ratios, and evaluated their cancer preventive effects on N‐nitrosodiethylamine (NDEA)‐induced hepatocarcinogenesis. After 20 weeks of dietary intervention, Diet I and Diet II reduced incidence, size, and number of hepatic nodules (p < 0.01) and prevented hepatic tumor formation in NDEA‐induced hepatocarcinogenesis rats. Low‐grade hepatic dysplasia incidence was 20% for Diet II and 40% for Diet I, and apparent hepatocellular carcinomas (HCC) rates were both 0, while 90% HCC in control diet treatment group (p < 0.01). Diet I and Diet II ameliorated abnormal liver function enzymes, reduced serum alpha fetal protein, tumor‐specific growth factor, dickkopf‐related protein 1, tumor necrosis factor‐alpha and interleukin‐6 levels, regulated hepatic phase I and II xenobiotic‐metabolizing enzymes, enhanced antioxidant capacity, suppressed NDEA‐initiated oxidative DNA damage, and induced apoptosis coupled to down‐regulation of proinflammatory, invasion, and angiogenesis markers. Daily intake of combination diet produced from ACEs‐rich elite crop varieties can effectively prevent or delay occurrence and development of NDEA‐induced hepatocarcinogenesis in rats. |
format | Online Article Text |
id | pubmed-6341211 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63412112019-01-24 Preventive effects of combinative natural foods produced by elite crop varieties rich in anticancer effects on N‐nitrosodiethylamine‐induced hepatocellular carcinoma in rats Zheng, Jingui He, Jun Liao, Sufeng Cheng, Zuxin Lin, Jinke Huang, Ke Li, Xiaocen Zheng, Kaibin Chen, Xuanyang Lin, Lihui Xia, Fagang Liu, Jianghong Xu, Ming Chen, Tuansheng Huang, Xinying Cao, Xiaohua Yang, Zhijian Food Sci Nutr Original Research The World Cancer Research Fund International has released 32 anticancer effects (ACEs) that targeted every stage of cancer processes. Thus, we designed two formulas of natural food combination Diet I and Diet II, mainly produced by elite crop varieties rich in ACEs with different mixture ratios, and evaluated their cancer preventive effects on N‐nitrosodiethylamine (NDEA)‐induced hepatocarcinogenesis. After 20 weeks of dietary intervention, Diet I and Diet II reduced incidence, size, and number of hepatic nodules (p < 0.01) and prevented hepatic tumor formation in NDEA‐induced hepatocarcinogenesis rats. Low‐grade hepatic dysplasia incidence was 20% for Diet II and 40% for Diet I, and apparent hepatocellular carcinomas (HCC) rates were both 0, while 90% HCC in control diet treatment group (p < 0.01). Diet I and Diet II ameliorated abnormal liver function enzymes, reduced serum alpha fetal protein, tumor‐specific growth factor, dickkopf‐related protein 1, tumor necrosis factor‐alpha and interleukin‐6 levels, regulated hepatic phase I and II xenobiotic‐metabolizing enzymes, enhanced antioxidant capacity, suppressed NDEA‐initiated oxidative DNA damage, and induced apoptosis coupled to down‐regulation of proinflammatory, invasion, and angiogenesis markers. Daily intake of combination diet produced from ACEs‐rich elite crop varieties can effectively prevent or delay occurrence and development of NDEA‐induced hepatocarcinogenesis in rats. John Wiley and Sons Inc. 2018-11-29 /pmc/articles/PMC6341211/ /pubmed/30680188 http://dx.doi.org/10.1002/fsn3.896 Text en © 2018 The Authors. Food Science & Nutrition published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Zheng, Jingui He, Jun Liao, Sufeng Cheng, Zuxin Lin, Jinke Huang, Ke Li, Xiaocen Zheng, Kaibin Chen, Xuanyang Lin, Lihui Xia, Fagang Liu, Jianghong Xu, Ming Chen, Tuansheng Huang, Xinying Cao, Xiaohua Yang, Zhijian Preventive effects of combinative natural foods produced by elite crop varieties rich in anticancer effects on N‐nitrosodiethylamine‐induced hepatocellular carcinoma in rats |
title | Preventive effects of combinative natural foods produced by elite crop varieties rich in anticancer effects on N‐nitrosodiethylamine‐induced hepatocellular carcinoma in rats |
title_full | Preventive effects of combinative natural foods produced by elite crop varieties rich in anticancer effects on N‐nitrosodiethylamine‐induced hepatocellular carcinoma in rats |
title_fullStr | Preventive effects of combinative natural foods produced by elite crop varieties rich in anticancer effects on N‐nitrosodiethylamine‐induced hepatocellular carcinoma in rats |
title_full_unstemmed | Preventive effects of combinative natural foods produced by elite crop varieties rich in anticancer effects on N‐nitrosodiethylamine‐induced hepatocellular carcinoma in rats |
title_short | Preventive effects of combinative natural foods produced by elite crop varieties rich in anticancer effects on N‐nitrosodiethylamine‐induced hepatocellular carcinoma in rats |
title_sort | preventive effects of combinative natural foods produced by elite crop varieties rich in anticancer effects on n‐nitrosodiethylamine‐induced hepatocellular carcinoma in rats |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341211/ https://www.ncbi.nlm.nih.gov/pubmed/30680188 http://dx.doi.org/10.1002/fsn3.896 |
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