Molecular Dynamics Simulations of A27S and K120A Mutated PTP1B Reveals Selective Binding of the Bidentate Inhibitor

Protein tyrosine phosphatase 1B (PTP1B) is considered a potential target for the treatment of type II diabetes and obesity due to its critical negative role in the insulin signaling pathway. However, improving the selectivity of PTP1B inhibitors over the most closely related T-cell protein tyrosine...

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Detalles Bibliográficos
Autores principales: Chen, Xi, Liu, Xia, Gan, Qiang, Feng, Changgen, Zhang, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341276/
https://www.ncbi.nlm.nih.gov/pubmed/30729132
http://dx.doi.org/10.1155/2019/9852897

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